Scrub Typhus Infection Induced Cardiovascular Disease
关键词
抽象
描述
Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi confined to East Asia including South Korea. It is characterized by fever, headache, rash, and eschar and the majority of patients without complications can recover with an early diagnosis and proper management with antibiotics. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia. Severe complications can be manifested by respiratory distress syndrome, renal failure, hepatic failure, and cardiovascular disease. Especially, cardiovascular complications can lead to cardiogenic shock and sudden cardiac arrest. Therefore, the association and predictors for scrub typhus induced cardiovascular disease should be investigated to provide a timely and appropriate diagnosis and to reduce the mortality rate of complicated scrub typhus infection. Therefore, investigators prospectively investigate the association and predictors of cardiovascular disease in the participants with scrub typhus infection admitted to 3rd referral centers in South Korea.
日期
最后验证: | 09/30/2019 |
首次提交: | 09/02/2017 |
提交的预估入学人数: | 09/05/2017 |
首次发布: | 09/06/2017 |
上次提交的更新: | 10/06/2019 |
最近更新发布: | 10/08/2019 |
实际学习开始日期: | 08/31/2017 |
预计主要完成日期: | 08/29/2020 |
预计完成日期: | 08/29/2021 |
状况或疾病
干预/治疗
Other: No intervention
相
手臂组
臂 | 干预/治疗 |
---|---|
Scrub typhus without cardiovascular complications Any participants with the scrub typhus infection without cardiovascular complication will be enrolled as a positive control group during admission and clinically followed by 1 year after discharge | |
Scrub typhus with cardiovascular complication Any participants with the scrub typhus infection with cardiovascular complication will be enrolled as a comparison group during admission and clinically followed by 1 year after discharge |
资格标准
有资格学习的年龄 | 19 Years 至 19 Years |
有资格学习的性别 | All |
取样方式 | Probability Sample |
接受健康志愿者 | 没有 |
标准 | Inclusion Criteria: - any participants with scrub typhus infection Exclusion Criteria: - patients under age of 18 - pregnancy |
结果
主要结果指标
1. Cardiovascular Mortality [one year]
次要成果指标
1. Cardiovascular Complications [one year]