Stevia Extract and Glucose Homeostasis
关键词
抽象
描述
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
日期
| 最后验证: | 03/31/2020 |
| 首次提交: | 04/01/2020 |
| 提交的预估入学人数: | 04/01/2020 |
| 首次发布: | 04/05/2020 |
| 上次提交的更新: | 04/06/2020 |
| 最近更新发布: | 04/08/2020 |
| 实际学习开始日期: | 03/02/2020 |
| 预计主要完成日期: | 02/14/2021 |
| 预计完成日期: | 02/14/2021 |
状况或疾病
干预/治疗
Other: sugar replacements
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| No Intervention: Water 250 ml of water mixed with 1g of citric acid. | |
| Active Comparator: Sugar 65g of sugar dissolved in 250ml of water | |
| Experimental: Stevia 5g of stevia dissolved in 250ml of water |
资格标准
| 有资格学习的年龄 | 18 Years 至 18 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Age 18-65 years - BMI 27-40 Kg/m2 - Males and females Exclusion Criteria: - Athletes - Pregnant or breastfeeding women - Patients with chronic disease (diabetes, CVD etc…). |
结果
主要结果指标
1. Postprandial glucose levels [Capillary blood glucose will be measured two hours after the administration of a fixed meal.]
次要成果指标
1. Postprandial insulin levels [Postprandial insulin levels will be measured two hours of the administration of a fixed meal]
2. Area under the curve (AUC) for glucose [Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch]
3. Subjective feelings of satiety [VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.]
