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The Effect of Berries on Lung Cancer Tumors

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赞助商
University of Louisville
合作者
James Graham Brown Cancer Center

关键词

抽象

The purpose of this study is to determine how berries affect cancer tumors in patients with non-small cell lung cancer.

描述

In the United States, more people (161,840 per year) die of lung cancers than of prostate cancer, breast cancer and colon cancer combined. Presently, there are over 43 million current smokers and over 47 million ex-smokers living in the US. Due to the lag time between smoking and the development of cancer, there are significant numbers of ex-smokers and current smokers who may develop lung cancer compared to never smokers.

Recent studies in animals have shown that berries, given as a dietary supplement, are highly effective against certain types of cancers. In a study involving mice with lung tumors, mice that had consumed a mixture of berries developed fewer tumors and had less tumor growth than mice that did not consume berries.

The berries used in this study will consist of blueberries, black raspberries, or a mixture of both.

日期

最后验证: 01/31/2018
首次提交: 05/18/2008
提交的预估入学人数: 05/19/2008
首次发布: 05/20/2008
上次提交的更新: 02/02/2018
最近更新发布: 02/05/2018
实际学习开始日期: 03/31/2008
预计主要完成日期: 11/30/2013
预计完成日期: 11/30/2013

状况或疾病

Non Small Cell Lung Cancer

干预/治疗

Dietary Supplement: berry powder

-

资格标准

有资格学习的年龄 18 Years 至 18 Years
有资格学习的性别All
接受健康志愿者
标准

Inclusion Criteria (lung cancer survivors):

- men treated for lung cancer, women treated for lung cancer and with no child-bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (lung cancer survivors):

- women who are on hormone replacement therapy

- women who are pregnant, or planning for pregnancy

- history of lung transplant

- prison inmate

- inability to take oral medication or food

- known or suspected allergy to berries or berry products

- HIV patients

Inclusion Criteria (volunteers):

- adult men, adult women with no child bearing potential (hysterectomy, tubal ligation, post-menopausal women)

Exclusion Criteria (volunteers):

- women who are on hormone replacement therapy

- women who are pregnant, or planning for pregnancy

- history of lung transplant

- prison inmate

- inability to take oral medication or food

- known or suspected allergy to berries or berry products

- HIV patients

结果

主要结果指标

1. Assessment of blueberry and black raspberry phenolics in plasma and urine [upon completion of 4 to 5 weeks of daily consumption of berry powder]

In addition to determining the berry phytochemical profile in plasma and urine, this study will attempt to establish the effect of berries on modulating immunological profiles such as the complete blood count, and T, B and natural killer (NK) cell populations and circulating biomarkers (serum proteins and microRNAs). This pilot study will establish the safety and feasibility of conducting a larger clinical trial with berry intervention.

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