The Role of Antidepressants or Antipsychotics in Preventing Psychosis
关键词
抽象
日期
最后验证: | 10/31/2012 |
首次提交: | 10/31/2012 |
提交的预估入学人数: | 11/05/2012 |
首次发布: | 11/08/2012 |
上次提交的更新: | 05/22/2014 |
最近更新发布: | 05/25/2014 |
实际学习开始日期: | 09/30/2012 |
预计主要完成日期: | 04/30/2014 |
预计完成日期: | 04/30/2014 |
状况或疾病
干预/治疗
Drug: Antidepressant
Drug: Antipsychotic
相
手臂组
臂 | 干预/治疗 |
---|---|
Experimental: Antidepressant Fluoxetine | Drug: Antidepressant |
Active Comparator: Antipsychotic Aripiprazole | Drug: Antipsychotic |
资格标准
有资格学习的年龄 | 12 Years 至 12 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - 12-25 years of age (inclusive) - Able to understand and speak English - Have at least one sub-threshold positive psychotic symptom that is moderate, moderately severe, or severe Exclusion Criteria: - Lifetime diagnosis of an Axis I psychotic disorder: schizophreniform disorder; schizophrenia; schizoaffective disorder; bipolar disorder; or major depression with psychotic features - Current psychosis - Current diagnosis of Major Depressive Disorder, single episode or recurrent, severe without psychotic features - Lifetime diagnosis of substance abuse or dependence (excluding nicotine) - Current stimulant treatment - Any significant medical condition that contra-indicates treatment with either aripiprazole or fluoxetine, including history of neurological, neuroendocrine or other medical condition known to affect the brain - Estimated intelligence quotient < 70 |
结果
主要结果指标
1. Attenuated positive, negative and general psychiatric symptoms [6 months]
次要成果指标
1. Social and role functioning [6 months]
2. Time to all-cause discontinuation. [6 months]
3. Adverse effects [6 months]