The Therapeutic Effect of Exercise Training on Patients With Dementia
关键词
抽象
描述
Exercise training has been evidenced to bring various of benefits for patients with dementia in past studies. However, whether strength training or aerobic training could bring better benefits has not been confirmed in the past. This study designed to recruit 30 patients with mild dementia in the first year. Every patient will receive strength training using dumbbells, butterfly machine and vertical leg press machine for four weeks. Outcome measures including self care ability, cognitive function, MCP-1, BDNF and IGF-1 levels, and the degree of depression will be recorded before and after the training. In the second year, the investigators also designed to recruit 31 patients with mild dementia. These participants will instead receive aerobic training using stationary bicycle for four weeks. The same outcome measures will be tested as in the first year. Via the results of this study, whether strength training or aerobic training could bring better benefits in dementia patient can thus be elucidated.
日期
| 最后验证: | 12/31/2018 |
| 首次提交: | 01/12/2019 |
| 提交的预估入学人数: | 01/16/2019 |
| 首次发布: | 01/21/2019 |
| 上次提交的更新: | 01/19/2019 |
| 最近更新发布: | 01/22/2019 |
| 实际学习开始日期: | 04/08/2018 |
| 预计主要完成日期: | 12/25/2018 |
| 预计完成日期: | 12/25/2018 |
状况或疾病
干预/治疗
Device: Strength training
Device: Aerobic training
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Strength training Muscle strength training programs | Device: Strength training Using dumbbells, butterfly machine and vertical leg press machine for strength training, 12 repetition maximum weight for 12 repetition, three times a day, five days a week, for a total of four weeks |
| Experimental: Aerobic training Aerobic training programs | Device: Aerobic training Using stationary bicycle to perform cardiopulmonary endurance training in 50-70 heart rate reserve for 20 minutes, five days per week, for a total of four weeks |
资格标准
| 有资格学习的年龄 | 65 Years 至 65 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion criteria: 1. Patients aged above 65 years old 2. Patients with mild dementia with Mini-mental state examination scoring 15 to 26 Exclusion criteria: 1. Cardiopulmonary diseases or orthopedical conditions that prohibit the patient from receiving exercise training of our programs 2. Cognitive problems that impede the patient to understand and answer the content of our questionnaires. |
结果
主要结果指标
1. Barthel index [4 weeks]
2. Mini-mental state examination [4 weeks]
3. Montreal Cognitive Assessment [4 weeks]
4. Geriatric Depression Scale [4 weeks]
次要成果指标
1. Concentration of serum brain derived neurotrophic factor (BDNF) [4 weeks]
2. Concentration of plasma insulin-like growth factor-1 (IGF-1) [4 weeks]
3. Concentration of plasmamonocyte chemotactic protein-1 (MCP-1) [4 weeks]
