To Study the Pathophysiological Features of Multiple Sclerosis
关键词
抽象
日期
最后验证: | 12/31/2019 |
首次提交: | 01/20/2020 |
提交的预估入学人数: | 01/22/2020 |
首次发布: | 01/26/2020 |
上次提交的更新: | 01/22/2020 |
最近更新发布: | 01/26/2020 |
实际学习开始日期: | 02/19/2020 |
预计主要完成日期: | 09/29/2020 |
预计完成日期: | 09/29/2020 |
状况或疾病
干预/治疗
Drug: Using image to diagnosis Multiple sclerosis (MS)
相
手臂组
臂 | 干预/治疗 |
---|---|
Other: Using image to diagnosis Multiple sclerosis (MS) In current study, we will enroll 38 patients with MS and evaluate their clinical severity; measure the WM lesion and disease activity by magnetic resonance imaging (MRI); myelination state and amyloid deposition by amyloid PET scan; tau deposition by state of-art tau PET scan | Drug: Using image to diagnosis Multiple sclerosis (MS) 18F-PM-PBB3 brain PET studies will be conducted for 38 subjects. Dynamic PET/MRI studies will be collected by PET/MRI scanner for 100 minutes (4×15 s, 8×30 s, 960 s, 2×180 s, 8300 s, 3×600 s). Volumes of interest (VOIs) will be delineated from corresponding MR images by manual including bilateral frontal, parietal, mesial temporal, lateral temporal, hippocampal, occipital, anterior cingulate, posterior cingulate, cerebellum areas, and genu region of white matter. The DVRs will be computed from Logan graphic analysis by using cerebellum as reference input.
SUVR of every cortical VOI to the gray matter of cerebellum will be calculated from nine 10-min dynamic image sets. |
资格标准
有资格学习的年龄 | 20 Years 至 20 Years |
有资格学习的性别 | All |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: 1. Age between 20-75 years old 2. Multiple Sclerosis patients Exclusion Criteria: 1. Implantation of metal devices including cardiac pacemaker, intravascular metal devices. 2. Major systemic diseases including coronary arterial disease, heart failure, uremia, hepatic failure, prominent strokes, acute myocardial infarction, poorly controlled diabetes, previous severe head injury, intracranial operation, hypoxia, sepsis or severe infectious diseases. 3. Major psychiatric disorders, drug or alcohol abuse and major depression 4. Pregnant women or breast- feeding women. 5. Patients in whom MRI was contraindicated or patient had claustrophobia. 6. History of severe allergic or anaphylactic reactions particularly to the tested drugs. 7. History of positive test for human immunodeficiency virus (HIV). 8. Indication of impaired liver function as shown by an abnormal liver function profile at screening (eg. repeated values of aspartate aminotransferase [AST] and alanine aminotransferase [ALT] ≧ 3X the upper limit of normal values). |
结果
主要结果指标
1. Correlation between hyperintensity lesions in FLAIR MRI and demyelination in amyloid PET image [3 years]
次要成果指标
1. Correlation between clinical parameters (EDSS) and hyperintensity lesions in FLAIR MRI and hyperintensity region of tau PET image light chain and GFAP levels. [3 years]
2. Correlation between clinical parameters (EDSS) and serum NfL levels [3 years]