Trial of Ibudilast for Methamphetamine Dependence

Inclusion Criteria:

1. 18 years of age or older;

2. meet DSM-IV-TR criteria for MA dependence (SCID verified);

3. a MA-positive urine drug screen at one or more visit during the two week lead-in period;

4. seeking treatment for MA problems;

5. willing and able to comply with study procedures;

6. provide written informed consent;

7. English speaking

8. reside within 35 miles of the clinical research site; and

9. if female of childbearing potential, not pregnant or lactating and willing to use a medically reliable method of birth control during the trial (e.g., birth control pills, Depo-Provera, and/or condoms with spermicide).

Exclusion Criteria:

1. a medical condition that, in the study physician's judgment, may interfere with safe study participation (e.g., active TB; unstable cardiac, renal, or liver disease; uncontrolled hypertension; unstable diabetes);

2. CD4 count < 50 cells/mm3 (suggestive of advanced HIV infection)

3. AST, ALT, or GGT > 3 times upper normal limit;

4. A corrected QT of > 450 msecs in men or > 460 msec in women on at least two ECGs during the baseline period, or clinical risk factors for Torsades de Pointes (e.g. (e.g., heart failure, hypokalemia, family history of Long QT Syndrome), or requiring ongoing treatment with concomitant medication(s) with established risk of Torsades de Pointes (e.g. Amiodarone, Arsenic trioxide, Astemizole, Bepridil, Chloroquine, Chlorpromazine, Cisapride, Citalopram, Clarithromycin, Disopyramide, Dofetilide, Domperidone, Droperidol, Erythromycin, Flecainide, Halofantrine, Haloperidol, Ibutilide, Levomethadyl, Mesoridazine, Methadone, Moxifloxacin, Pentamidine, Pimozide, Probucol, Procainamide, Quinidine, Sotalol, Sparfloxacin, Terfenadine, Thioridazine, Vandetanib);

5. current ongoing treatment with psychotropic medications (e.g., antidepressants, antipsychotics, antiepileptics, sedative/hypnotics, narcotic analgesics);

6. a neurological disorder (e.g., organic brain disease, dementia) or a medical condition which would make study agent compliance difficult or which would compromise informed consent;

7. a major psychiatric disorder not due to substance abuse (e.g., schizophrenia, bipolar disorder) as assessed by the SCID;

8. attempted suicide in the past 3 years and/or serious suicidal intention or plan in the past year as assessed by the C-SSRS;

9. currently on prescription medication that is contraindicated for use with IBUD including alpha or beta agonists, theophylline, or other sympathomimetics;

10. current dependence on cocaine, opiates, alcohol, or benzodiazepines as defined by DSM-IV-TR;

11. alcohol dependence within the past year;

12. greater than one urine specimens during the lead-in with a riboflavin concentration of < 900 ng/ml as assessed via UV fluorescence;

13. a history of sensitivity to IBUD; or

14. any other circumstances that, in the opinion of the investigators, would compromise participant safety;

15. current participation in another clinical trial.