Vascular Effects of Triglyceride-rich Lipoproteins
关键词
抽象
日期
| 最后验证: | 08/31/2019 |
| 首次提交: | 06/07/2012 |
| 提交的预估入学人数: | 06/10/2012 |
| 首次发布: | 06/12/2012 |
| 上次提交的更新: | 09/11/2019 |
| 最近更新发布: | 09/15/2019 |
| 实际学习开始日期: | 05/31/2012 |
| 预计主要完成日期: | 09/30/2012 |
| 预计完成日期: | 09/30/2012 |
状况或疾病
干预/治疗
Dietary Supplement: High-fat meals varying in their fatty acid composition
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Active Comparator: Oleic acid 75 g high oleic acid sunflower oil. | |
| Active Comparator: Linoleic acid 75 g high linoleic acid sunflower oil. | |
| Experimental: Eicosapentaenoic acid and docosahexaenoic acid 5 g EPA and DHA derived from fish oil, made up to a total of 75 g with high oleic sunflower oil. | |
| Experimental: Docosahexaenoic acid 5 g DHA derived from algal oil, made up to a total of 75 g with high oleic sunflower oil. |
资格标准
| 有资格学习的年龄 | 35 Years 至 35 Years |
| 有资格学习的性别 | Male |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Healthy males - Non-smokers - Aged 35-70 years - Fasting TAG concentrations ≥1.2 mmol/L. Exclusion Criteria: - Reported history of CVD (myocardial infarction, angina, venous thrombosis, stroke), impaired fasting glucose/uncontrolled type 2 diabetes (or fasting glucose ≥ 6.1 mmol/L), cancer, kidney, liver or bowel disease. - Presence of gastrointestinal disorder or use of drug, which is likely to alter gastrointestinal motility or nutrient absorption. - History of substance abuse or alcoholism (previous weekly alcohol intake >60 units/men) - Current self-reported weekly alcohol intake exceeding 28 units - Allergy or intolerance to any component of test meals - Unwilling to restrict consumption of any source of fish oil for the length of the study - Weight change of >3kg in preceding 2 months - Body Mass Index <20 and >35 kg/m2 - Fasting blood cholesterol > 7.8 mmol/L - Current cigarette smoker. - Current use of lipid lowering medication |
结果
主要结果指标
1. Activation of inflammatory/oxidative stress pathways within cultured endothelial cells following treatment with 6 h postprandial chylomicron remnant-rich lipoprotein fraction [6 h post-meal]
次要成果指标
1. Incremental area under the plasma concentration versus time curve (iAUC) of triacylglycerol [0, 1, 2, 3, 4, 5 and 6 h post-meal]
2. Incremental area under the plasma concentration versus time curve (iAUC) of glucose [0, 1, 2, 3, 4, 5 and 6 h post-meal]
3. Incremental area under the plasma concentration versus time curve (iAUC) for non-esterified fatty acids [0, 1, 2, 3, 4, 5 and 6 h post-meal]
4. Incremental area under the plasma concentration versus time curve (iAUC) for plasma fatty acid composition (%) [0, 1, 2, 3, 4, 5 and 6 h post-meal]
5. Incremental area under the plasma concentration versus time curve (iAUC) for cholesterol [0, 1, 2, 3, 4, 5 and 6 h post-meal]
6. Incremental area under the unit measure versus time curve for brachial augmentation index [0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 and 360 min post-meal]
7. Incremental area under the unit measure versus time curve for systolic blood pressure [0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 and 360 min post-meal]
8. Incremental area under the unit measure versus time curve for diastolic blood pressure [0, 30, 60, 90, 120, 150, 180, 210, 240, 270, 300, 330 and 360 min post-meal]
9. Change in digital volume pulse stiffness index [0, 2, 4 and 6 h post-meal]
10. Change in digital volume pulse reflection index [0, 2, 4 and 6 h post-meal]
11. Change in plasma nitrite/nitrate concentrations [0, 2, 4 and 6 h]
12. Change in plasma 8-isoprostane F2alpha concentrations [0, 2, 4 and 6 h post-meal]
13. Activation of inflammatory/oxidative stress pathways within cultured endothelial cells following treatment with 4 h postprandial chylomicron remnant-rich lipoprotein fraction [4 h post-meal]
14. Activation of inflammatory/oxidative stress pathways within cultured endothelial cells following treatment with 5 h postprandial chylomicron remnant-rich lipoprotein fraction [5 h post-meal]
