Vasopressin and V2 Receptor in Meniere's Disease
关键词
抽象
描述
Methods: Between 1998 and 2006, we enrolled and assigned 105 intractable Meniere's patients to examine plasma vasopressin during remission of vertigo attacks (controls: 30 patients with chronic otitis media). Using the real-time PCR method, we examined V2R mRNA expression in the endolymphatic sac in 12 patients (controls: 6 patients with acoustic neurinoma). By means of cell culture and cyclic AMP assay, we also examined cyclic AMP activity in the endolymphatic sac in 3 patients (controls: 3 patients with acoustic neurinoma).
日期
| 最后验证: | 12/31/2007 |
| 首次提交: | 01/09/2008 |
| 提交的预估入学人数: | 01/21/2008 |
| 首次发布: | 01/22/2008 |
| 上次提交的更新: | 03/27/2016 |
| 最近更新发布: | 03/28/2016 |
| 实际学习开始日期: | 03/31/1998 |
| 预计主要完成日期: | 08/31/2005 |
| 预计完成日期: | 08/31/2005 |
状况或疾病
干预/治疗
Genetic: 1. Meniere's disease
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: 1. Meniere's disease Patients were eligible for enrollment if they had received a clinical diagnosis of Meniere's disease according to the 1995 AAO-HNS criteria (Committee, 1995). These criteria can be briefly described as follows: 1) Repeated attacks of vertigo: A definitive spell is spontaneous vertigo lasting at least 20 minutes. A mixed type of spontaneous nystagmus is observed during attacks. 2) Fluctuating cochlear symptoms: The hearing test usually reveals a marked fluctuation of the threshold in the low and middle tone range. | Genetic: 1. Meniere's disease plasma vasopressin, V2 receptor, cyclic AMP |
| No Intervention: 2. Acoustic neurinoma Diagnosed by CT and/or MRI |
资格标准
| 有资格学习的年龄 | 20 Years 至 20 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Patients were eligible for enrollment if they had received a clinical diagnosis of Meniere's disease according to the 1995 AAO-HNS criteria (Committee, 1995). These criteria can be briefly described as follows: 1. Repeated attacks of vertigo: A definitive spell is spontaneous vertigo lasting at least 20 minutes. A mixed type of spontaneous nystagmus is observed during attacks. 2. Fluctuating cochlear symptoms: The hearing test usually reveals a marked fluctuation of the threshold in the low and middle tone range. Exclusion Criteria: - Any other neuro-otologic diseases. |
结果
主要结果指标
1. plasma vasopressin level and V2 receptor mRNA in the endolymphatic sac in Meniere's disease vs controls [prospective]
次要成果指标
1. cyclic AMP activity in the endolymphatic sac in Meniere's disease vs controls [prospective]
