Vitamin D and COVID-19 Management
关键词
抽象
描述
In-patients
1. Determine the frequency of low serum Vit D levels (<50 nmol/L) in COVID-19 patients.
2. Determine the relationship between baseline vitamin D status and disease severity, laboratory biochemical tests of white blood cell count (WBC), C-reactive protein (CRP), lymphocyte count, leukocytes counts and neutrophil-lymphocyte-ratio (NLR), lactate dehydrogenase, IL-6, IL-1beta, TNF-alpha platelet count, albumin, and serum ferritin, required hospitalization and intensive care unit (ICU) admission.
3. Asses patients' initial response to vitamin D supplementation in week one and determine its association with disease progression and recovery.
4. Compare disease severity and progression, laboratory biochemical tests of white blood cell count (WBC), C-reactive protein (CRP), lymphocyte count, lactate dehydrogenase, IL-6, IL-1beta, TNF-alpha, platelet count, albumin, and serum ferritin, hospital admission and length of stay, duration of mechanical ventilation, hospital mortality and respiratory failure differ between the early responder and non-responder groups.
Out-patients
1. Determine the frequency of low serum Vit D levels (<50 nmol/L) in COVID-19 patients.
2. Determine the relationship between baseline vitamin D deficiency and clinical characteristics.
3. Asses patients' response to vitamin D supplementation in week three and determine its association with disease progression and recovery
日期
| 最后验证: | 05/31/2020 |
| 首次提交: | 05/07/2020 |
| 提交的预估入学人数: | 05/10/2020 |
| 首次发布: | 05/12/2020 |
| 上次提交的更新: | 06/02/2020 |
| 最近更新发布: | 06/04/2020 |
| 实际学习开始日期: | 05/31/2020 |
| 预计主要完成日期: | 07/31/2020 |
| 预计完成日期: | 11/30/2020 |
状况或疾病
干预/治疗
Dietary Supplement: High dose vitamin D
Dietary Supplement: Low dose vitamin D
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: High dose vitamin D Ddrops® products,Vitamin D3, 50,000 IU, Oral | Dietary Supplement: High dose vitamin D Vitamin D3 |
| Active Comparator: Low dose vitamin D Vitamin D3 1000IU | Dietary Supplement: Low dose vitamin D Vitamin D3 1000IU |
资格标准
| 有资格学习的年龄 | 17 Years 至 17 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: Patients with COVID-19: - ≥ 17 years old - Both sexes Exclusion Criteria: - Patients with dementia, learning disability, mental health needs and alcohol or drug dependency, pregnant women will be excluded. - Patients with sarcoidosis, hypercalcemia, known vitamin D intolerance |
结果
主要结果指标
1. Symptoms recovery [Time from onset of intervention to day 21]
次要成果指标
1. Hospitalization [Between diagnosis and day 21]
2. Blood white blood cell count (WBC) [At day 0 before starting intervention and day 21 of intervention]
3. Duration of mechanical ventilation [Between diagnosis and day 21]
4. Duration of hospitalization [Between diagnosis and day 21]
5. Intensive care unit (ICU) admission [Between diagnosis and day 21]
6. Duration of ICU stay [Between diagnosis and day 21]
7. Blood C-reactive protein (CRP) [Baseline and day 21]
8. Blood Lymphocyte count [Baseline and day 21]
9. Blood Ferritin [Baseline and day 21]
10. Blood platelet count [Baseline and day 21]
11. Blood interleukin-6 (IL-6) [Baseline and day 21]
12. Blood Tumor Necrosis Factor alpha (TNF) [Baseline and day 21]
