Vitamin D Level vs Semen Parameters
关键词
抽象
描述
-Idiopathic male infertility is known as idiopathic oligoasthenoteratozoospermia, which indicates that the men have an unexplained reduction of semen quality.
In contrast, unexplained male infertility is defined as infertility of unknown origin with normal sperm parameters.
Furthermore, optimal strategies for treating idiopathic male infertility have also remained unclear.
- Data from studies in humans suggest that vitamin D receptors are present in testis, epididymis, prostate and seminal vesicles. The level of expression varies, being higher in epididymis and seminal vesicles.
- Vitamin D receptors expression was also evident in Leydig cells, as well as in normal and abnormal sperm, with the acrosomal region and the neck being the sites with the most abundant messenger ribonucleic acid expression.
- The 1,25(OH)2 D3 molecule increases intracellular calcium concentrations, sperm motility and acrosin activity, and reduces triglyceride content in sperm, actions that significantly contribute to fertilising capacity within the female reproductive tract.
日期
| 最后验证: | 12/31/2019 |
| 首次提交: | 05/22/2017 |
| 提交的预估入学人数: | 05/23/2017 |
| 首次发布: | 05/24/2017 |
| 上次提交的更新: | 01/20/2020 |
| 最近更新发布: | 01/21/2020 |
| 实际学习开始日期: | 04/30/2020 |
| 预计主要完成日期: | 06/30/2020 |
| 预计完成日期: | 06/30/2020 |
状况或疾病
干预/治疗
Diagnostic Test: semen sample
Diagnostic Test: blood sample
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| idiopathic male infertility total of 30 male patients with idiopathic male infertility.
Semen samples will be collected from all patients Semen analysis will be examined after 2-5 days of sexual abstinence based on World Health Organization (WHO) (2010).
blood samples will be taken &the following will be done Serum vitamin D level ,Serum calcium level ,Serum testosterone level ,luteinizing hormone (LH), and follicle-stimulating hormone (FSH), will be measured. | |
| fertile male group total of 30 fertile male (as control)
Semen samples will be collected,Semen analysis will be examined after 2-5 days of sexual abstinence based on World Health Organization (WHO) (2010).
blood samples will be taken &the following will be done Serum vitamin D level ,Serum calcium level ,Serum testosterone level ,luteinizing hormone (LH), and follicle-stimulating hormone (FSH), will be measured. |
资格标准
| 有资格学习的性别 | Male |
| 取样方式 | Probability Sample |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - infertile male patients without any detectable cause with normal clinical examination and abnormal semen parameters. Exclusion Criteria: - Cases with known etiology or apparent physical finding ,leukocytospermia, diminished testicular volume ,varicocele or an abnormal hormonal profile. - couples with combined male and female factor will be excluded. |
结果
主要结果指标
1. correlation between vitamin D level and semen parameters [baseline]
