Vulvodynia: Identification of Potential Relevant Biomarkers
关键词
抽象
描述
Sphingosine-1-phosphate (S1P) is a potent anti-apoptotic sphingolipid with potent pro-inflammatory actions which are driven in most part by activation of the S1P receptor subtype S1PR158. Biologically active S1P is generated by the phosphorylation of sphingosine, catalyzed by two sphingosine kinases (SphK1, SphK2). S1P levels are further regulated by its dephosphorylation by two phosphatases (SGPP1 and SGPP2) and through degradation by one lyase (SGPL1). Once released S1P initiates signaling through a family of five cognate G protein-coupled receptors (S1PR1-5), leading to various cellular responses9. S1P signaling has important roles in inflammation and cancer. S1P acting via the S1PR1 has been implicated in the development of pain of several etiologies as discovered by Salvemini and coworkers and subsequently extended by others. FTY720 (fingolimod/Gilenya®) is the first orally available agent approved by the FDA for the treatment of relapsing-remitting multiple sclerosis (MS). The work by Salvemini's group in providing a mechanistic basis for understanding chronic pain through the S1P/S1PR1 axis, provides a promising therapeutic target for the use of agents like FTY720 as a novel treatment for pain. Ongoing work by the Salvemini's lab suggests that increased expression of S1PR1 in circulating peripheral blood leukocytes (PBLs) may provide a relevant biomarker to predict severity and pain induction outcomes as well as predict patient responses to anti-S1PR1 approaches.
日期
最后验证: | 05/31/2020 |
首次提交: | 11/29/2016 |
提交的预估入学人数: | 11/30/2016 |
首次发布: | 12/04/2016 |
上次提交的更新: | 06/14/2020 |
最近更新发布: | 06/15/2020 |
实际学习开始日期: | 03/12/2019 |
预计主要完成日期: | 06/09/2020 |
预计完成日期: | 07/31/2020 |
状况或疾病
相
资格标准
有资格学习的年龄 | 18 Years 至 18 Years |
有资格学习的性别 | Female |
取样方式 | Probability Sample |
接受健康志愿者 | 是 |
标准 | Inclusion Criteria: - 18-70 years of age - Vulvar pain of at least 3 months' duration - Localized (e.g. vestibulodynia, clitorodynia) or Generalized or Mixed - Provoked or Spontaneous or Mixed Onset - Temporal pattern Exclusion Criteria: - <18 or >70 years of age - pregnant - Not able to provide consent - Patients with active vulvar dystrophies. |
结果
主要结果指标
1. S1PR1 elevation [up to one year]