Xylitol Disk Use in Adults With Dry Mouth
关键词
抽象
描述
Xylitol,an FDA approved sugar substitute, has been shown to reduce tooth decay. Patients who experience dry mouth may be more susceptible to dental decay because they lack the protection provided by an adequate flow of saliva. These patients are likely to have high levels of the decay causing bacteria, mutans streptococci.
The purpose of this research is to test the ability of a novel xylitol delivery vehicle to reduce mutans streptococci in patients with dry mouth over a two week period. The delivery vehicle is a slowly dissolving xylitol disk (lozenge) that adheres to soft tissues inside the mouth. Participants will place disks on both sides of the mouth three times a day.
日期
| 最后验证: | 11/30/2013 |
| 首次提交: | 03/26/2013 |
| 提交的预估入学人数: | 03/26/2013 |
| 首次发布: | 04/03/2013 |
| 上次提交的更新: | 11/30/2013 |
| 最近更新发布: | 12/02/2013 |
| 实际学习开始日期: | 02/28/2013 |
| 预计主要完成日期: | 07/31/2013 |
| 预计完成日期: | 07/31/2013 |
状况或疾病
干预/治疗
Other: Xylitol disk
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Xylitol disk Daily use of 8 disks containing 0.5 grams xylitol each for two weeks. The disks adhere to gum tissue with a food grade adhesive backing and slowly dissolve. The disks are applied one on each side of the mouth in the morning after breakfast, again at midday, and four are applied, two on each side, at bedtime. | Other: Xylitol disk |
资格标准
| 有资格学习的年龄 | 21 Years 至 21 Years |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - Adults 21 years old or older - Daily use of at least 2 prescription medications known to cause dry mouth - Current report of dry mouth Exclusion Criteria: - Antibiotic use in the last month - Topical oral antimicrobial (e.g. Chlorhexidine rinse) use in the last month - Change in medication or dose within the last month - Use of mouthwash within the last week - Use of lozenges or chewing gum with 500 mg or more of xylitol on a habitual basis - History of gastrointestinal disease |
结果
主要结果指标
1. Mutans streptococci levels [One week]
2. Mutans streptococci levels [Two weeks]
次要成果指标
1. GRIX measure of xerostomia [One week]
2. GRIX measure of xerostomia [Two weeks]
