Zinc Bioavailability From Amaranth-enriched Maize Tortillas
关键词
抽象
描述
This is a randomized cross-over study of zinc absorption in young children living in the Western Highlands of Guatemala. Absorption of zinc will be measured from maize tortillas and maize tortillas fortified with 20% amaranth as the major food staple which provides at least 70% energy and at least 90% zinc and phytate of the diet. Participants will be randomized as to which type of tortilla they receive on the first and second day. Fractional absorption of zinc (FAZ) from all meals in one day for one type of tortilla and one day for the other will be measured by extrinsic labeling with stable isotopes of zinc. FAZ will be measured by a dual isotope tracer ratio (DITR) technique based on ratio of urine enrichment of orally versus intravenously administered zinc stable isotopes. Measurement of total zinc in duplicate diets on test days allow for determination of quantities of this micronutrient absorbed.
日期
| 最后验证: | 03/31/2016 |
| 首次提交: | 07/31/2014 |
| 提交的预估入学人数: | 08/03/2014 |
| 首次发布: | 08/04/2014 |
| 上次提交的更新: | 04/26/2016 |
| 最近更新发布: | 04/28/2016 |
| 实际学习开始日期: | 12/31/2011 |
| 预计主要完成日期: | 11/30/2015 |
| 预计完成日期: | 11/30/2015 |
状况或疾病
干预/治疗
Other: Maize Tortillas with 20% Amaranth
Other: Maize Tortillas without 20% Amaranth
相
手臂组
| 臂 | 干预/治疗 |
|---|---|
| Experimental: Maize Tortillas with 20% Amaranth Children in this arm were fed maize tortillas fortified with 20% amaranth | Other: Maize Tortillas with 20% Amaranth Subjects received Maize tortillas with 20% Amaranth added. |
| Experimental: Maize Tortillas without 20% Amaranth Children in this arm were fed maize tortillas without amaranth | Other: Maize Tortillas without 20% Amaranth Maize tortillas without Amaranth. |
资格标准
| 有资格学习的年龄 | 18 Months 至 18 Months |
| 有资格学习的性别 | All |
| 接受健康志愿者 | 是 |
| 标准 | Inclusion Criteria: - 2-3 years of age - apparently healthy - eats >2-3 tortillas at each meal of the day. Exclusion Criteria: - Chispitas or macrovital supplementation - breastfeeding - birth weight < 2,500 g - birth defect affecting growth and development - chronic infection - twin or triplet - sibling enrolled in study |
结果
主要结果指标
1. Zinc Absorption [2 days]
