Addition of Selenium Improves Immunomodulative Effects of Glucan.
关键词
抽象
BACKGROUND
Selenium (Se) is an established essential nutrient that plays a role in various biological processes including cancer development. Similarly, stimulation of immune reactions by β-glucans is well-documented.
OBJECTIVE
In the current study, we focused on the stimulation of phagocytosis and interleukin (IL)-2 production and on potentiation of anticancer immunity by a combination of glucan with two types of Se.
METHODS
Phagocytosis was evaluated using synthetic microspheres; cancer development was measured either using breast cancer cells or using lung cancer cells.
RESULTS
Using two different murine models of cancer, we showed that the Se/glucan combination strongly suppressed the growth of cancer, mostly probably via stimulation of immunity.
CONCLUSIONS
A combination of glucan with Se offers superior stimulation of immunity and inhibition of cancer growth.
