Journal of Natural Products 2004-Feb
Antimycobacterial Naphthopyrones from Senna obliqua.
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
关键词
抽象
Bioactivity-directed fractionation of the methanolic extract of the stem and fruits of Senna obliqua led to the isolation of two known antimycobacterial natural products, quinquangulin (1) and rubrofusarin (2). Both compounds had minimum inhibitory concentrations (MICs) of 12.0 microg/mL against Mycobacteriatuberculosis in radiometric culture. This is the first report of antimycobacterial activity associated with naphthopyrone compounds. Their structures were determined by spectroscopic means including 1D and 2D NMR techniques and further confirmed by X-ray crystallographic analysis.