Indian Journal of Dermatology, Venereology and Leprology
Methotrexate Therapy For Psoriasis(A Preliminary Report).
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Fourteen patients, 9 males and 5 females with chronic severe intractable psoriasis resistant to conventional therapies were treated with methotrexate. Five had psoriatic erythroderma while 9 had extensive disease. Methotrexate therapy given orally in weekly single doses of 20-30 mg was effective in all cases. The side effects observed included nausea and vomiting headache, pain abdomen, diffuse alopecia and loss of appetite.