Journal of Enzyme Inhibition and Medicinal Chemistry 2006-Oct
Novel urease inhibitors from Daphne oleoids.
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Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of the Daphne oleoids led to the isolation of the coumarin glycosides 1-6. Compound 5 with IC50 values 22.05 and 26.30 microM repectively, was found to be the most active of these compounds when screened against Bacillus pasteurii and jack bean urease enzymes in a concentration-dependent fashion.