Zeitschrift fur Naturforschung. Section C, Biosciences
Potential anticancer agents, XI. X-ray structure determination of acantholide.
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The X-ray structure of acantholide, a melampolide sesquiterpene lactone from Acanthospermum glabratum (DC.) Willd. was determined by the aid of direct methods. The compound was cytotoxic but displayed no antitumor activity. Evaluation of the X-ray and NMR data indicated that the same conformation exists in the solid state as in solution.