Clinical Laboratory 2014
Symptomatic factor XIII deficiency with normal urea solubility test.
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关键词
抽象
BACKGROUND
Factor XIII deficiency is a rarely encountered bleeding disorder traditionally identified by clot dissolution in 5 molar urea (urea solubility test).
METHODS
We report a patient with delayed post-surgical bleeding characteristic of factor XIII deficiency with a normal urea solubility test.
RESULTS
Factor XIII deficiency was identified by an automated assay that measured factor XIII antigen. The patient was successfully treated with cryoprecipitate.
CONCLUSIONS
Patients with excessive bleeding with normal screening tests should be tested for factor XIII using a sensitive assay procedure. The urea solubility assay for factor XIII should be discontinued due to its lack of sensitivity.
