Journal of Organic Chemistry 2006-Aug
Synthesis and stereochemistry of the antitumor diterpenoid (+)-zerumin B.
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
关键词
抽象
Starting from commercially available (+)-sclareolide, the first synthesis of zerumin B was achieved by a concise, highly efficient pathway featuring stereoselective addition of a new silyloxyfuryltitanium reagent to an aldehyde intermediate and silyloxyfuran oxyfunctionalization as key steps. The synthesis established the relative and absolute configuration of zerumin B along with its identity with a purportedly new diterpenoid isolated from the plant Renealmia alpinia.