The amnesic syndrome of primary Whipple disease of the brain.
关键词
抽象
OBJECTIVE
To describe a case of primary Whipple disease (WD) of the brain, which may manifest as an amnesic syndrome.
METHODS
A 46-year-old woman developed primary WD of the brain. The onset was characterized by a short-term amnesic syndrome for several months before the onset of generalized tonic-clonic seizures. Her amnesia was stable throughout her illness.
RESULTS
Our patient had impairment of verbal and visual memory tasks with reduced learning. Her amnesic syndrome was secondary to asymmetric bilateral hippocampal atrophy with gliosis involving the mesial temporal structures-all secondary to primary WD of the brain.
CONCLUSIONS
WD may present as an amnesic syndrome and needs to be thought of as a treatable cause of cognitive dysfunction in young adults.