The genus Tamarix L., with the common name of tamarisk, consists of more than 60 species of halophyte plants which are used for medicinal purposes such as infections, wounds, and liver and spleen disorders by local people mostly in Asian and African countries.In spite of the potential health benefits of Tamarix spp., the plant is not yet well-known in modern medicine; thus, the aim of the present review is to provide a critical appraisal of the current state of the art regarding the ethnomedicinal uses, phytochemistry, and pharmacological properties of Tamarix spp.Electronic databases (Medline, Cochrane library, Science Direct, and Scopus) were searched with the words "Tamarix" and "Tamarisk" to collect all available data regarding different Tamarix species from the inception until May 2019.Tamarix spp. is traditionally used for gastrointestinal disorders, wounds, diabetes, and dental problems. Phenolic acids, flavonoids, and tannins constitute the main phytochemicals of these plants. Preclinical pharmacological evaluations have demonstrated several biological activities for Tamarix spp. including antidiabetic, hepatoprotective, wound healing, and anti-inflammatory; however, no clinical evidence have yet been provided to support the health benefits of these plants.Tamarix spp. are plants rich in polyphenolic compounds with valuable medicinal properties; though, there are several methodological problems such as lack of a mechanistic approach and taxonomic ambiguities in the current available data. High-quality preclinical studies, as well as well-designed clinical trials are necessary to confirm the safety and efficacy of these plants in humans.
