Trends in Pharmacological Sciences 1994-Feb
Vasoconstrictor and vasodilator effects of hypoxia.
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
关键词
抽象
Hypoxia has marked effects on artery calibre, which reflects important physiological control mechanisms that are altered in disease states. Hypoxia modifies the release of mediators, especially from the endothelium, and influences smooth muscle membrane potential and Ca2+ regulation. In this review, Roger Wadsworth evaluates the vasoconstrictor and vasodilator effects of hypoxia studied in vitro. In the future, drugs developed to act on the mediators or smooth muscle may be beneficial in the therapy of, for example, pulmonary hypertension or coronary vasospasm.