Clinical Gastroenterology and Hepatology 2020-Feb
Contained Aortic Rupture With Hematoma and Gastrointestinal Bleeding.
只有注册用户可以翻译文章
登陆注册
链接已保存到剪贴板
关键词
抽象
CREB3 (Luman) is a family member of ER resident transcription factors, which are cleaved upon the induction of ER stress. Their N-terminal fragments shuttle into the nucleus where they regulate the transcription of target genes. Here, we found that human CREB3 is phosphorylated within its transcription activation domain on serine 46 by protein kinase CK2. Further analyses revealed that the phosphorylation of this site does neither affect the cleavage by S1P/S2P proteases, nor the nuclear localisation nor the transcriptional activity of CREB3. However, phosphorylation at serine 46 reduced the stability of CREB3.