1 4 naphthoquinone/dental caries

1,2-naphthoquinone (1,2-NQ) and 1,4-naphthoquinone (1,4-NQ) are clinically promising biologically active chemicals that have been shown to stimulate the aryl hydrocarbon receptor (AhR) signaling pathway, but whether they are direct or indirect ligands or activate the AhR in a ligand-independent

The purpose of the present study was to investigate the interaction between both hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and PVP-K30 with 2-hydroxy-N-(3-methyl-5-ethyl-4-isoxazolyl)-1,4-naphthoquinone-4-imina (I), a synthetic derivative of isoxazolylnaphthoquinones that has demonstrated to

A heterometallic octanuclear coordination cage [Os₄Zn₄(L^nap)₁₂]X₁₆ (denoted Os•Zn; X = perchlorate or chloride) has been prepared (L^nap is a bis-bidentate bridging ligand containing two pyrazolyl-pyridine chelating units separated by

A series of nine new compounds bridged by acyl groups at the 5,8-dihydroxyl group of DHNQ were synthesized and their cytotoxic activity against L1210 and P388 cancer cells was examined. Their antitumor action in mice bearing S-180 cells in the peritoneal cavity was also assessed. Increasing the size

The combination of molecular modeling methods to identify the putative binding site of inhibitors constitutes an important tool in drug discovery. In this work, we used these analyses to understand the potent inhibitory effect of naphthoquinone derivatives on heat shock protein 90 (Hsp90), one of

1,4-Naphthoquinones are widely distributed in nature and many clinically important antitumor drugs containing a quinone moiety, such as anthracyclines, mitoxantrones and saintopin, show excellent anticancer activity. In this study, 2- or 6-substituted 5,8-dimethoxy-1,4-naphthoquinone (DMNQ) and

Background: Dental caries is considered to be a preventable disease, and various antimicrobial agents have been developed for the prevention of dental disease. However, many bacteria show resistance to existing agents.