5 结果
FIELD OF THE INVENTION
The present invention relates to diazepane-acetamide derivatives as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin
FIELD OF THE INVENTION
The present invention relates to diazepane-acetamide derivatives as selective inhibitors of the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11.beta.-HSD-1) and the use of such compounds for the treatment and prevention of metabolic syndrome, diabetes, insulin
FIELD OF THE INVENTION
The invention is directed to 4-substituted-cyclohexylamino-4-piperidiyl-acetamide compounds, which are antagonists to the chemoattractant cytokine receptor 2 (CCR2), pharmaceutical compositions, and methods for use thereof. Compounds of the invention are useful for preventing,
CROSS REFERENCE TO RELATED APPLICATIONS
This application is based on, and claims priority from, provisional application 60/022,056 filed on Jul. 22, 1996.
SUMMARY OF THE INVENTION
This invention is concerned with a novel process for the synthesis of compounds 9 and 10, both key intermediates in the
This application is a U.S. national stage of International Application No. PCT/JP2008/054093 filed Mar. 6, 2008.
TECHNICAL FIELD
The present invention relates to a benzoxazepine derivative having a superior serotonin 5-HT.sub.2C receptor activation action and useful as a drug for the treatment or