Patients in the B group were given berberine hydrochloride tables 0.3g tid orally or tube feed daily, until the 14th day of the study. Other treatments include general support therapy, oxygen therapy, antiviral drugs, in combination with antibiotics and small doses of glucocorticoids if necessary, nutritional and organ function support.

Patients in the C group were given montmorilonite orally if they presence of diarrhea. The other treatments were the same as in B group.

Berberine

COVID-19

Patients in the intervention group received berberine daily, regardless of gastrointestinal symptoms.If the patient has a serious drug-related adverse event, the drug will be discontinued and the patient will be excluded from the study.

Patients in the control group were routinely not given special treatment.However, if the patient has diarrhea symptoms, montmorillonite powder should be given orally.

Montmorrillonite

Nanjing Drum Tower Hospital

The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19

Including diarrhea in times/day, Bristol Stool Scale (the minimum 1 and maximum 7, a higher scores mean a worse outcome) and whether patient has any one of gastrointestinal symptoms (nausea, vomiting, abdominal pain, abdominal distension or diarrhoea).

evaluate inflammatory response, blood sample collected at 6:00am

evaluate the severity of the disease(the minimum 0 and maximum 24, a higher scores mean a worse outcome)

We have other articles about covid-19 yet to be published

Chinese Medical Association

A combination of two alkaloid, Protopine and Nuciferine

Bladder Cancer

LUTS

Pain

A combination of two alkaloid, Protopine and Nuciferine (Protoves-M1 ®)

Protoves M1®

Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations

The Role of Protopine Associated With Nuciferine (Protoves M1® Syrup) in Controlling Adverse Event During HIVEC® Instillations

The International Prostate Symptom Score (I-PSS) is based on the answers to some questions concerning urinary symptoms and one question concerning quality of life.

The OAB-q SF 6 is a questionnaire developed to evaluate the overactive bladder symptom and health-related quality of life.

The PPIUS is a questionnaire developed to evaluate the patient perception of intensity of urgency

PGI-I is a validated tool to estimate the improvement or the deterioration associated to the treatment.

Visual analogue scales (VAS) are 10-cm lines anchored at the ends by words that define the bounds of various pain dimensions.

Qmax (ml/s) is the maximum flow rate at uroflowmetry

Post-Void residual (ml) measures the amount of urine left in the bladder after urination.

Francesco Chiancone

Assistant Medical Director, Principal Investigator

Cardarelli Hospital

A urinary balloon catheter will be placed through the cervix into the lower uterine segment and the bulb inflated with 40ml of saline. The catheter will be taped to the patient's thigh and placed under traction using a liter bag of saline. The catheter will be deflated and removed after 6 hours. If spontaneously expelled from the uterus, time of expulsion will be noted. Six hours after insertion of catheter, a digital exam will be performed and Bishop score recorded. If no active labor at time of catheter removal or expulsion, standardized protocol of oxytocin will commence. Labor management will be at the discretion of the physician.

Prepidil Only : Prepidil gel will be inserted into the vaginal fornix according to manufacturer's direction. No oxytocin or other intervention will commence until 6 hours after insertion of gel. Six hours after insertion of gel, digital exam will be performed and Bishop score recorded. If no active labor 6 hours after the administration of gel, standardized protocol of oxytocin will commence. Labor management will be at the discretion of the physician.

A urinary balloon catheter will be placed through the cervix into the lower uterine segment and the bulb inflated with 40ml of saline. The catheter will be taped to the patient's thigh and placed under traction using a liter bag of saline. Prepidil gel will be inserted through the catheter into the lower uterine segment, in a dose equivalent to manufacturer's recommendation. No oxytocin or other intervention will commence until 6 hours after insertion of the catheter and administration of prepidil gel (even if catheter is spontaneously expelled). After 6 hours, digital exam will be performed and Bishop score recorded. If no active labor, standardized protocol of oxytocin will commence.

A urinary balloon catheter will be placed through the cervix into the lower uterine segment and the bulb inflated with 40ml of saline. The catheter will be taped to the patient's thigh and placed under traction using a liter bag of saline. The catheter will be deflated and removed after 6 hours. If spontaneously expelled from the uterus, time of expulsion will be noted. Six hours after insertion of catheter, a digital exam will be performed and Bishop score recorded. If no active labor at time of catheter removal or expulsion, standardized protocol of oxytocin will commence. Labor management will be at the discretion of the physician.
Urinary Balloon Catheter: Pre-induction cervical ripening using a urinary balloon catheter device.

Urinary Balloon Catheter Only

Prepidil gel will be inserted into the vaginal fornix according to manufacturer's direction. No oxytocin or other intervention will commence until 6 hours after insertion of gel. Six hours after insertion of gel, digital exam will be performed and Bishop score recorded. If no active labor 6 hours after the administration of gel, standardized protocol of oxytocin will commence. Labor management will be at the discretion of the physician.
Dinoprostone Gel: Pre-induction cervical ripening using dinoprostone gel in the vagina.

Prepadil Only

A urinary balloon catheter will be placed through the cervix into the lower uterine segment and the bulb inflated with 40ml of saline. The catheter will be taped to the patient's thigh and placed under traction using a liter bag of saline. Prepidil gel will be inserted through the catheter into the lower uterine segment, in a dose equivalent to manufacturer's recommendation. No oxytocin or other intervention will commence until 6 hours after insertion of the catheter and administration of prepidil gel (even if catheter is spontaneously expelled). After 6 hours, digital exam will be performed and Bishop score recorded. If no active labor, standardized protocol of oxytocin will commence.
Urinary Balloon Catheter Device and Dinoprostone Gel: Pre-induction cervical ripening using dinoprostone gel injected through a urinary balloon catheter placed in the lower uterine segment.

Combined Urinary Catheter & Prepadil Gel

Total

Sex: Female, Male

Region of Enrollment

The primary outcome of this study is vaginal delivery of a liveborn singleton pregnancy. The outcome is considered a vaginal delivery if accomplished by spontaneous vaginal delivery, operative forceps or vacuum forceps. The alternate outcome is delivery by cesarean section.

Vaginal Delivery

Overall Study

Meg Hill, MBBS

Failed Labour

Pre-induction cervical ripening using dinoprostone gel in the vagina.

Prepidil Gel

Pre-induction cervical ripening using a urinary balloon catheter device.

Urinary Balloon Catheter

Pre-induction cervical ripening using dinoprostone gel injected through a urinary balloon catheter placed in the lower uterine segment.

Combined Urinary Catheter & Prepidil Gel

Palmetto Health Richland Hospital

Comparison of Pre-Induction Cervical Ripening

Comparison of Pre-Induction Cervical Ripening Using Prepidil Gel Administered Through a Urinary Balloon Catheter.

University of South Carolina

HIV Infections

Giant Lymph Node Hyperplasia

Rituximab

Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapy

Multicenter, Phase II Trial Assessing the Efficacy of Rituximab in HIV Infected Patients With Multicentric Castleman Disease Dependent on Chemotherapy (ANRS 117 Study, CastlemaB)

alkaloid/fever

The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19

Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations

Comparison of Pre-Induction Cervical Ripening

Rituximab in the Treatment of HIV Associated Multicentric Castleman Disease Dependent on Chemotherapy

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