anophthalmos/fever

Pregnant rats at day 9 were bathed in 43 degrees C water for 15 min. Maternal rats at day 15 of gestation were found pregnant with fetuses variously malformed externally, such as exencephaly, spina bifida, microphthalmia, anophthalmia, facial cleft, cleft lip and generalized edema. Fetal death

Maternal hyperthermia induces severe malformations in the central nervous system (CNS) in both humans and laboratory animals. These phenomena are accompanied by apoptotic cell death, especially in the developing CNS. Cardiovascular malformations in conjunction with skeletal and CNS abnormalities

BACKGROUND Although hyperthermia is a recognized animal teratogen and maternal fever has been associated with birth defects in humans, data on the relationship between high environmental temperatures and birth defects are limited. OBJECTIVE To determine whether pregnancies are potentially vulnerable

The majority of patients with microphthalmos and colobomas have genetic disorders. This is a survey of non-inherited, sporadic microphthalmos. Such cases may occur in the Goldenhar, CHARGE and VATER associations; it may also be due to teratological agents, for instance maternal ingestion of drugs,

Pregnant women with influenza are at increased risk of morbidity, particularly due to respiratory complications. A high excess mortality rate among pregnant women has been observed in previous influenza pandemics and healthcare agencies have provided recommendations on the use of oseltamivir to