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A. Early detection of systemic relapses in breast cancer.
WP 1. Analysis of primary tumor.
Analysis of primary tumor and metastases (Pathology group). In this work package both DNA and RNA from the primary tumors of 125 high-risk (Luminal-B) patients will be analyzed by next-generation sequencing
A total of 20 patients will be enrolled for this feasibility study. Included in this study will be female adults at least 18 years of age with
1. A BMI of 35-39.99 and 1 or more severe obesity‐related co‐morbidities (including T2D, hypertension, hyperlipidemia, obstructive sleep apnea (OSA),
Cancer survivors are at an increased risk of bone loss due to previous cancer treatments and are at increased risk of obesity and other cardiometabolic diseases. Therefore it is important for cancer survivors to adhere to an active lifestyle and good nutrition. The study proposes a single site,
Despite the mortality rates among cancer patients have been greatly reduced as a result of medical advances in cancer screening and treatment in recent decades, cancer itself and the adverse effects of treatment are still threatening to young cancer patients, with vast destruction in both physical
Survival of childhood ALL exceeds 80% in an increasing number of many low-middle income countries (LMIC). Recent studies have found that the effects of obesity on survival are observed within the first several years of diagnosis, thus impacting immediate health outcome. Of concern is the developing
Introduction
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), typically diagnosed between the age of 15 and 40 and characterized by colonic mucosal inflammation and ulcerations. These mucosal changes lead to bloody diarrhea and in severe cases, fever, anemia, weight loss and
Obesity could increase the risk of many chronic diseases, including hypertension, cardiovascular diseases, high lipid level, diabetes, stroke, endometrial cancer and certain types of cancer which could benefit by secondary prevention through screening programs. In particular, colorectal, breast and
The "strong pulse disease" was treated by acupuncture, phlebotomy and leeches from 2600 to c. Modern history began when in 1628 William Harvey described the circulatory system and in 1733 stephen hales made the first blood pressure measurement. In 1896 was recognized as a clinical entity, thanks to
BACKGROUND Hematopoietic stem cell transplantation (HSCT) is a potentially curative option for many diseases, such as hematologic malignancies and refractory solid tumors among children and adolescents. This procedure led to considerable improvement in survival rates, but also contributed to the
Brief Overview:
The remarkable progress in developing curative therapy for childhood cancer over the last 4 to 5 decades has increased awareness of the serious cancer treatment-related late effects experienced by long-term survivors such as premature mortality early deaths, second primary cancers,
Aim To evaluate the effects of opioid sparing care pathways compared to conventional opioid-based treatment for pain relief, opioid consumption, recovery after surgery, self-efficacy and health economy in patients undergoing obesity surgery. The aim will be investigated by a prospective, randomized,
Cervical cancer is the second most frequent cancer in Mexican women, representing 16.9% of the total female population. At the National Cancer Institute of Mexico (Instituto Nacional de Cancerología), 80% cervical cancer patients arrive at locally advanced stages (IB2-IVA). Standard treatment for