Major Depressive Disorder

5-hydroxytryptophan and Creatine

Placebo control

University of Utah

Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females

A Randomized, Double-blind, Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression Associated With Hypobaric Hypoxia in Females

The purpose of this study is to determine if 8 weeks of dietary augmentation with oral 5 g creatine daily and 100 mg 5-HTP twice daily reduces hypoxia-related depressive symptoms measured by the 17-item Hamilton Depression Rating Scale (HAM-D) in women with SSRI or SNRI resistant depression

Brent Kious

Instructor

Four risk areas reflecting the great needs of FCGs of PWDs: depressive symptoms, burden, distress to problematic behaviors of PWDs and healthy behaviors.

Dementia

The intervention involves home visits & phone calls from the case manager to the dyads, and receiving telephone calls from FCGs. The case manager will target the prioritized risk from the 4 risk areas of FCG problems and healthy behaviors. The intervention mainly consists of needs assessment and nursing education on home environment modification and safety, behavioral management and communication skills; home-based cognitive stimulation on PWD with simple mathematical practice, patient preferred leisure activities and reminiscence by old time photos, stories and toys; brief consultation on 4 risk areas related to FCG stress; and case management to refer the dyads to the hospital-based dementia centers and community resources.

Four risk areas reflecting the great needs of FCGs of PWDs

Catholic Mercy Hospital

Theoretical Based Case Management Intervention for Dementia Family Caregivers

The FCG QoL will be measured by the composite score of the measures from the 4 risk areas of FCGs for PWDs using The Center for Epidemiologic Depression (CESD-10), Chinese Caregiving Burden Scale (CBS), Neuropsychological Inventory (NPI) caregiver distress scale, and Health Promotion Profile.

The secondary outcome of the CM intervention is yielding to FCG role based on PWD status: staying at home, admitting to hospital and admitting to nursing home. The time of events and days of staying will be collected through FCGs.

Yi-Chien, Chiu

Associate Professor

Chang Gung University

Chang Gung Memorial Hospital

5-hydroxytryptophan and Creatine monohydrate

Open Label Treatment With 5-HTP and Creatine

Sex: Female, Male

Ethnicity (NIH/OMB)

Race (NIH/OMB)

The purpose of this study is to determine if 8 weeks of dietary augmentation with oral 5 g creatine daily and 100 mg 5-HTP twice daily reduces hypoxia-related depressive symptoms measured by the 17-item Hamilton Depression Rating Scale (HAM-D) in women with SSRI or SNRI resistant depression. HAM-D (outcome measure) was used to assess the level of depression at baseline and after 8 weeks of using the study drug. The Hamilton Depression Rating Scale ranges from 0 to 50. A score of 0-7 is considered to be normal. A score of 8-13 indicates mild depression. A score of 14-18 indicates moderate depression. Scores higher than 19 indicate severe depression.

Change From Baseline in Hamilton Depression Rating Scale

Overall Study

Brent Kious, MD, PhD

University of Utah/The Brain Institute

5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females

Perry Renshaw

MD, PhD, MBA

We call Exposed group to increased TI > or = 0.05ng/ml We call Event to the onset of ARDS

We cal no Exposed group to increased TI (<0.05ng/ml) We call Event to the onset of ARDS

ARDS

Karla Isis Aviles Martinez

Predictive Value of Troponin I for Acute Respiratory Distress Syndrome in Children With Shock

incidence of exposed , unexposed incidence , relative risk, attributable risk , absolute risk reduction

Sensibility, specificity, likelihoods ratio

KARLA ISIS AVILES MARTINEZ

MD Karla Isis Aviles Martinez

Hospital Civil de Guadalajara

Anaesthesia

receive intravenous injection of 0.2 mL/kg of saline 0.9%L [group P]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

Placebo [group P]

receive intravenous injection of 0.2 mL/kg of aminophylline 10 mg/mL [group A2]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 10 mg/mL [group A2]

receive intravenous injection of 0.2 mL/kg of aminophylline 15 mg/mL [group A3]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 15 mg/mL [group A3]

receive intravenous injection of 0.2 mL/kg of aminophylline 20 mg/mL [group A4]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 20 mg/mL [group A4]

receive intravenous injection of 0.2 mL/kg of aminophylline 25 mg/mL [group A5]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

0.2 mL/kg of aminophylline 25 mg/mL [group A5]

receive intravenous injection of 0.2 mL/kg of doxapram 5 mg/mL [group D]. All study solutions were injected within 1 min at T0 after discontinuation of sevoflurane. No stimulation was applied to patients during this period.

Doxapram 1 mg/kg [group D]

King Faisal University

Aminophylline and Cognitive Function After Sevoflurane Anaesthesia

Aminophylline Improves Early Postoperative Cognitive Recovery After Sevoflurane Anaesthesia: A Dose-Dependent Study

The SOMCT is a patient-based test designed to assess cognitive function in terms of level of orientation, memory, and concentration.

antidepressants/hypoxia

Placebo-controlled Trial of 5-hydroxytryptophan and Creatine for SSRI or SNRI Augmentation in Treatment Resistant Depression in Females

Theoretical Based Case Management Intervention for Dementia Family Caregivers

5-hydroxytryptophan and Creatine for Treatment Resistant Depression Associated With Hypoxia in Females

Predictive Value of Troponin I for Acute Respiratory Distress Syndrome in Children With Shock

Aminophylline and Cognitive Function After Sevoflurane Anaesthesia

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