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BACKGROUND OF THE INVENTION
Morphological changes occur in the adult vertebrate brain both during normal learning and in various neuropathologies such as epilepsy and Alzheimer's disease (Refs. 1-3). These changes include neurodegeneration and more subtle remodeling of the cellular architecture, and
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
BACKGROUND OF THE INVENTION
Apoptosis, or programmed cell death (PCD), is a genetically regulated mechanism with a central role in both metazoan development and homeostasis. (Raff, 1992; Steller, 1995). The cell death machinery is conserved throughout evolution (Vaux et al., 1994) and is composed of
FIELD OF INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists of
1. FIELD OF THE INVENTION
This invention relates to novel compositions comprising one or more of an acid protease enzyme and an acidic buffer, the acidic buffer comprising an acid and a pharmaceutically or cosmetically acceptable carrier, useful for treating or preventing abnormal skin conditions,
FIELD OF THE INVENTION
This invention relates to novel compositions comprising one or more of an acid protease enzyme and an acidic buffer, the acidic buffer comprising an acidic buffering component that can reversibly disassociate hydrogen ions and has buffering capacity at pH values below that of
SEQUENCE LISTING
A sequence listing submitted in computer readable format is hereby incorporated by reference. The computer readable file is named P224717sequencelist_ST25.txt, was created on Mar. 25, 2013, and contains 260 kilobytes. A supplementary sequence listing, submitted in computer readable
REFERENCES AND INCORPORATION BY REFERENCE
Complete bibliographic citations for the references cited herein are contained in a section titled "REFERENCES," immediately preceding the claims. All of the documents listed in the "REFERENCES" section are incorporated herein.
FIELD OF THE INVENTION
The
This application is a U.S. national stage of International Application No. PCT/EP2006/061152 filed Mar. 29, 2006.
FIELD OF THE INVENTION
The invention relates to a method for determining whether a compound is a neurotrypsin inhibitor, to particular inhibitors of neurotrypsin, to the use of such
CROSS-REFERENCE TO RELATED APPLICATIONS
This is a 371 National Stage Entry of International Application No. PCT/AT2007/000393, filed Aug. 16, 2007, which claims priority of Austrian Patent Application No. A 1376/2006, filed Aug. 16, 2006, the contents of which are incorporated herein in their
TECHNICAL FIELD
This application relates to a novel use of cancer markers such as kallikreins, including prostate-specific antigen (PSA), as inhibitors of angiogenesis useful for treating angiogenesis-related diseases such as angiogenesis-dependent cancer. The invention further relates to novel
TECHNICAL FIELD
This application relates to a novel use of cancer markers such as kallikreins, including prostate-specific antigen (PSA), as inhibitors of angiogenesis useful for treating angiogenesis-related diseases such as angiogenesis-dependent cancer. The invention further relates to novel
BACKGROUND OF THE INVENTION
Evolution in mammals, reptiles, birds and fish has developed extraordinarily efficient musculoskeletal systems for generating and controlling motion. However, the musculoskeletal system is not only an efficient system for delivering useful mechanical energy and load