6 结果
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to stable aqueous solution preparations containing azulene sodium sulfonate as an active ingredient, which are suited for use as a preventive or therapeutic medicine for inflammatory diseases in digestive organs,
BACKGROUND OF THE INVENTION
Metalloproteins play an important role in many physiological and pathophysiological processes. The metalloproteins are accordingly divided into various groups corresponding to their substrate. Many metalloproteins hydrolyze proteins (metalloproteases), while others cleave
RELATED APPLICATIONS
The present application is a 371 National Stage of PCT/IB2014/000707 filed on May 12, 2014, which claims the benefit of Indian Provisional Patent Application No. 1718/MUM/2013 filed on May 14, 2013 and Indian Provisional Patent Application No. 2309/MUM/2013 filed on Jul. 9,
BACKGROUND OF THE INVENTION
1. Field of the Invention
The invention relates to a medicine, and in particular to azulene compounds which modulate the protein kinases (PKs) activity.
2. Description of the Related Art
Protein kinases (PKs) are enzymes which catalyze the phosphorylation of specific
Substituted 1,4,10-triazadibenzo[cd,f]azulenes, substituted 1,4,5,10-tetraazadibenzo[cd,f]azulenes and substituted 1,4,5,7,10-pentaazadibenzo[cd,f]azulenes as bromodomain inhibitors
BACKGROUND
Bromodomains refer to conserved protein structural folds which bind to N-acetylated lysine residues that are found in some proteins. The BET family of bromodomain containing proteins is comprised of four members (BRD2, BRD3, BRD4 and BRDt). Each member of the BET family employs two
FIELD OF THE INVENTION
Present invention relates to a low dose pharmaceutical composition, preferably oral composition comprising therapeutically effective amount of [(2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H,5H-10-thia-1,4a-diaza-benzo[a]- azulene-3-carbonyl)-amino]-acetic acid (compound A) in the