azulene/neoplasms

BACKGROUND OF THE INVENTION The invention had the object of finding novel compounds having valuable properties, in particular those which can be used for the preparation of medicaments. The present invention relates to compounds and to the use of compounds in which the inhibition, regulation and/or

BACKGROUND OF THE INVENTION 1. Field of the Invention The invention relates to a medicine, and in particular to azulene compounds which modulate the protein kinases (PKs) activity. 2. Description of the Related Art Protein kinases (PKs) are enzymes which catalyze the phosphorylation of specific

BACKGROUND Bromodomains refer to conserved protein structural folds which bind to N-acetylated lysine residues that are found in some proteins. The BET family of bromodomain containing proteins is comprised of four members (BRD2, BRD3, BRD4 and BRDt). Each member of the BET family employs two

FIELD OF THE INVENTION The invention relates generally to compounds with anti-cancer activity and more specifically to compounds which inhibit PI3 kinase activity. The invention also relates to methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian