beriberi/tyrosine

Report on a serious disturbance of amino-acid metabolism in a 56 year old male patient suffering from thiamine-(vitamin B-1) deficiency, as proven by clinical history and examination and by laboratory data. In comparison with a group of 75 normal male persons also evaluated by the same laboratory

The metabolic effects of thiamine deficiency on the metabolism of lactate, acid-base and amino acids were evaluated both with and without muscular exercise in a controlled animal experiment. Thiamine deficiency - in good correlation with its biologic halftime and also with reports in the literature

Male Wistar rats maintained on a thiamine deficient diet showed mouse-killing behavior (muricide). On the 30th day of experimental feeding, the incidence of the muricide was 70%. Intraperitoneal (i.p.) injection of 3-(3,4-dihydroxyphenyl)-l-alanine (l-dopa) suppressed the muricide in a