Four-hour infusion of ethanol (0.5 g/kg.hr) and additional 2-hour infusion of caerulein (0.2 microgram/kg.hr) and secretin (0.2 CU/kg.hr) caused hyperamylasemia, pancreatic edema and pancreatic histological changes such as interstitial edema and acinar cell vacuolization in the rat. Such a combined