Chlorhexidine is one of the most commonly used medications after tooth extraction. It exhibits a wide spectrum of antiseptic, bactericidal and bacteriostatic effects.

Due to its antibacterial properties, boric acid is effective on gram (+) and gram (-) microorganisms such as candida albicans, streptococcus mutans, staphylococcus aureus, enterococcus faecalis, enterococcus faesium, escherichia coli, klebsiella pneumonia and pseudomonas aeruginosa. With these features, it is used in periodontology, endodontics and restorative therapy as a antiseptic.

Impacted Third Molar Tooth

After anesthesia, the horizontal incision was made with no. 15 scalpel blade and a full thickness mucoperiosteal flap was raised. In all surgical procedures, bone removal and/or tooth sectioning were performed under abundant irrigation. Following the extraction, granulation tissues were removed, and post extraction cavity was irrigated with sterile 0.9% saline solution. After the bleeding was controlled, the mucoperiosteal flap was repositioned by 3.0 silk sutures. The patients were postoperatively prescribed paracetamol (Parol® 500 mg, Atabay Chemical Industry, Istanbul, Turkey) to use when required with a maximum of 4 doses per day. Patients were instructed to maintain a soft diet, and refrain from mouth washing, brushing and flossing during the first 24 hour. They were also instructed to rinse their mouth with 15 ml of mouthwash for 30 seconds, 3 times a day, and continue until the 7th postoperative day.

Chlorhexidine mouthwash

Chlorhexidine mouthwash with boric acid (0.1%)

Chlorhexidine mouthwash with boric acid (0.5%)

Chlorhexidine mouthwash with boric acid (1%)

Chlorhexidine mouthwash with boric acid (1.5%)

Chlorhexidine mouthwash with boric acid (2%)

Chlorhexidine mouthwash with boric acid (2.5%)

Boric acid mouthwash (2%)

Van Yuzuncu Yil University, Faculty of Dentistry

Comparison of the Efficacy of Boric Acid Mountwashes in Different Concentrations

Comparison of the Efficacy of Boric Acid Mountwashes in Different Concentrations in the Lower Third Molar Surgery in the Postoperative Period

In order to evaluate the postoperative pain, a seven-day scheduled pain diary was given to the patients. To record the level of pain, patients were instructed to rate it on a 10-cm visual analog scales (VAS) was used wherein 0 indicated no pain and 10 indicated the worst pain imaginable.

Facial swelling was assessed using thread and millimeter ruler and five following measurements were taken: Distance I (from angle of the mandible to labial commissure); Distance II (from angle of the mandible to nasal border); Distance III (from angle of the mandible to external corner of the eye); Distance IV (from angle of the mandible to tragus) and Distance V (from angle of the mandible to soft pogonion).

The maximum mouth opening (MMO) was measured in millimeters with a caliper from the incisal edge of the right upper and lower incisor teeth. For evaluation of trismus, the percentage of difference in MMO during postoperative period was calculated by subtracting the preoperative measurement from the postoperative measurement then divided by the preoperative measurement and multiplied by 100.

levent Cigerim

Head of Oral and Maxillofacial Surgery Department

Yuzuncu Yıl University

The 72 healthy subjects enrolled were admitted to the trial ward the day before the trial. On the day of dosing, the subjects were given 0.1% meloxicam eye drops once, 1 drop / time.

Eight healthy subjects were enrolled in the trial ward the day before the trial. 0.1% meloxicam eye drops were administered 4 times, 1 drop / time, and were administered at 8:00, 12:00, 16:00 and 20:00 daily for 3 consecutive days.

Healthy Volunteers

Meloxicam

Institution of Drug Clinical Trials

Pharmacokinetic and Tolerance Study of Meloxicam Eye Drops in Healthy Volunteers

Pharmacokinetics and Tolerance of Meloxicam Eye Drops in Healthy Volunteers, a Phase I , Single-dose and Multiple-dose, Open-labeled Clinical Trial

In a single administration test, tear samples were collected 0.5, 1, 2, 4, 6, 8, 10, 12 and 24 hours after administration, and 8 eyes were taken at each time point.LC-MS

In the multiple dose tolerance test, IOP was performed 2 hours (± 20min) after the second dose of Day2.

Corneal fluorescence staining during the multiple dose tolerance test (Day1-Day3) 1 h after the last daily dose (time window ± 10 min).

Beijing Tongren Hospital

diabetic foot ulcer care with formulation gel: addition of borate as sodium penta boric acid pentahydrate 3% (w/v) and two different copolymer as pluronic block namely F68 2% (w/v) and f127 2% (w/v).

placebo gel containing polymer of carbopol ultrex (1%)

Diabetic Foot Ulcer

application of a formulation gel: addition of borate as sodium penta boric acid pentahydrate 3% (w/v) and two different copolymer as pluronic block namely F68 2% (w/v) and f127 2% (w/v) to diabetic foot ulcers.

boron gel

Placebo

Mustafa Hasbahceci

Effect of Local Application of Boron on Diabetic Foot Ulcers

Prospective Randomized Study of Local Application of Boron on Diabetic Foot Ulcers: Effect of Healing Process

healing and complete epithelization of diabetic foot ulcer with regard to time in weeks; comparison with progression or regression of grades of the wound based on classification sytems of International Working Group of the Diabetic Foot (IWGDF) and area of the wound measured as square centimeter.

development of local infective complications including osteitis, abscess, osteomyelitis and gangrene

improvement of inflammatory parameters in diabetic foot ulcers including leukocyte count, c-reactive protein and wound culture

boric acid/inflammation

Comparison of the Efficacy of Boric Acid Mountwashes in Different Concentrations

Pharmacokinetic and Tolerance Study of Meloxicam Eye Drops in Healthy Volunteers

Effect of Local Application of Boron on Diabetic Foot Ulcers

Topical Voltaren in Otitis Externa

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