bromelain/hypoxia

Bromelain, a pineapple-derived enzyme mixture, is a widely used drug to improve tissue regeneration. Clinical and experimental data indicate a better outcome of soft tissue healing under the influence of bromelain. Proteolytic, anti-bacterial, anti-inflammatory, and anti-oedematogenic effects

Dense extracellular matrix (ECM) severely impedes the spread of drugs in solid tumors and induce hypoxia reduces chemotherapy efficiency. Different proteolytic enzymes such as, collagenase (Col) or bromelain, can directly attach to the surface of nanoparticles and improve their diffusion, but the

Cancer therapy is routinely performed in the clinic to cure cancer and control its progression, wherein therapeutic agents are generally used. To reduce side effects, protherapeutic agents that can be activated by overexpressed cancer biomarkers are under development. However, these agents still