4 结果
OBJECTIVE
Buruli ulcer disease is endemic in many developing countries in Africa. It is caused by Mycobacterium ulcerans, a toxin-producing bacterium with predilection for the skin and its deeper tissues. The exact mode of transmission is unclear and the pathogenesis is also not well understood,
Background: In Japan, Buruli ulcer cases are often advanced, requiring surgical treatment. However, extensive debridement is often difficult because of cosmetic and functional sequelae. Moreover, the lesions are complicated and composed
Buruli ulcer is a chronic skin disease caused by Mycobacterium ulcerans, which produces a toxic lipid mycolactone. Despite the extensive necrosis and tissue damage, the lesions are painless. This absence of pain prevents patients from seeking early treatment and, as a result, many patients
In 1972 we reported the first isolation of M. ulcerans in Germany and in 1973 we reviewed the epidemiology, clinical features and therapy of Buruli ulcer (6, 7). Initial isolation was done from swabs of the edge of the ulcer on Loewenstein-Jensen medium at 30-33 degrees C. Subcultures showed poor