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A point mutation in PIK3CA, the gene encoding the α isoform of class I phosphatidylinositol 3-kinase, induces extensive remodeling of the transcriptome and proteome, resulting in a gene signature that specifically resembles that of the basal subtype, but not other types, of breast cancer.
Breast cancer is the biggest curse for the women society in the world since the survival factor of the infected patients is ensured only when it is detected at the early localized stage. The majority of the intelligent schemes proposed for detecting the breast cancer relies on the human skill that
The authors aim to present the butterfly effect, a concept based on the theory that small changes might have a powerful effect, as an example of the important connection between diet and acne. Western diet is currently a well known environmental factor which, mainly via the overstimulation of mTORC1
BACKGROUND
Evidence suggests a survival benefit for patients with glioblastoma who undergo maximal safe surgical resection. Not all glioblastomas are amenable to surgical resection and anatomic location is one potentially limiting factor. Glioblastomas that invade the corpus callosum and cross
BACKGROUND
The pathologies implicate the bilateral corpus callosum that builds the butterfly pattern on axial view. These tumors have seldom been investigated for both clinical manifestations and outcome.
OBJECTIVE
The objective of this study was to describe the clinical characteristics and outcomes
Endoscopic submucosal dissection (ESD) is the preferred technique for en bloc resection of superficial colorectal neoplasms. Resection of extensive lesions with ESD can be challenging, owing to loss of orientation in the submucosal space. In this case series, we describe the BACKGROUND
Anaplastic cortical ependymomas are rare lesions with few cases reported in the literature.
METHODS
We present a unique case of an anaplastic cortical ependymoma in a 51-year-old female presenting as a butterfly lesion with involvement of both frontal lobes. The patient underwent gross
Reactive gliosis was found in a 40-year-old man who presented with intractable seizures thought to be due to a malignant neoplasm. Although two separate lesions located bilaterally in the frontal lobes were evident on the computed tomographic scan, a connection between these lesions along the fibers
From late August to early September, millions of adult monarch butterflies of the eastern North American population cease reproducing, become highly gregarious and begin migrating southwards. By mid-October, they migrate through central Texas into Mexico where they follow the Sierra Madre Oriental
To address a paucity of literature and treatment guidelines regarding the management of butterfly glioblastomas, we performed a ten year retrospective analysis of data from twenty-three consecutive patients treated for this disease at a single institution. Clinical characteristics and outcomes were
The aim of the case reports section of Archivos de Bronconeumología is to bring together unusual cases representing a substantial contribution to our understanding of the pathophysiology or other clinical and biological features of a disease. During 2007, 17 case descriptions were published in this
We previously reported the presence of cytotoxic substances in extracts of the Danaid butterfly, Ideopsis similis. In the present study, we isolated cytotoxic substances against a human gastric cancer cell line, TMK-1, in I. similis pupae, with an activity similar to that of the adult butterfly. The
We described here a patient who presented with symptoms of heart failure who was found to have severe bilateral impairment of atrioventricular inflow. Primary cardiac lymphoma (PCL) with extensive involvement of the two atria, pericardium and myocardium is an extremely rare tumor in immunocompetent
Primary cardiac tumors are rare with a reported prevalence of 0.01-0.02% based on pooled autopsy series. Although most mobile cardiac tumors arising from the interatrial septum and extending into the atria are thought to be benign myxomas, this may often not be true. Myxoid fibrosarcomas which in
Chaos and natural evolution of tumor system have become two reasons of the failure of tumor therapies. Selectively targeting chaotic tumor systems to induce a "butterfly effect" is promising in constructing non-interventional and effective strategy for tumor therapy. Herein, we demonstrate