carissa macrocarpa/seizures

OBJECTIVE To investigate the anticonvulsant activity of root bark extract of Carissa edulis. METHODS The median lethal dose (LD(50)) of Carissa edulis extract was determined using Lork's method (1983). The anticonvulsant activity of the extract was assessed in pentylenetetrazole (PTZ)-induced

BACKGROUND Carissa edulis Vahl (Apocynaceae) is used in Nigerian folk medicine to manage a plethora of diseases including epilepsy, cancer, and inflammation; its efficacy is widely acclaimed among communities of northern Nigeria. OBJECTIVE This study establishes anticonvulsant activities of aqueous