celastrus gemmatus/scopolamine

BACKGROUND Treatment of memory impairment associated with dementia such as Alzheimer's disease is still inadequate and requires development of new drugs. OBJECTIVE The objective was to evaluate the memory enhancing effect of Celastrus paniculatus seed oil. METHODS C. paniculatus seed oil was mixed

Celastrus paniculatus (CP), a medicinal plant from India has been reputed to be useful as a pharmaceutical aid for learning and memory. We investigated the effects of the seed oil of CP on the 6 day performance of young adult rats in a navigational memory task-the Morris water maze. Chronic oral

Alzheimer's disease (AD) is an irreversible, multifaceted, and progressive neurodegenerative disorder. Over the past 30 years, the search for anti-AD drugs has been primarily based on the cholinergic deficiency hypothesis and/or the β-amyloid (Aβ) cascade hypothesis. In this study, we report the