corynanthine/ischemia

In isolated perfused rat hearts, global ischaemia for 20 or 40 min led to a substantial decrease of myocardial ATP, creatine phosphate and glycogen, and to an increase in lactate and glucose-6-phosphate. Subsequent coronary reperfusion was associated with severe tachyarrhythmias (ventricular

In isolated perfused rat hearts reperfusion of the occluded left coronary artery led to arrhythmias, their severity depending on the duration of the foregoing period of myocardial ischaemia. Simultaneously, high activities of the myocardial enzyme creatine kinase (CK) were released into the

In pentobarbital-anesthetized rats the left coronary artery was ligated for 5 or 30 min and then opened for reperfusion of the ischemic myocardial area. Twelve min prior to the coronary occlusion yohimbine stereoisomers, namely corynanthine and rauwolscine, or saline solution were given