The present invention relates to a novel pseudoceramide derivative, a pharmaceutically acceptable salt thereof or a solvate thereof, and a pharmaceutical or cosmetic composition containing the same as an active ingredient. The novel pseudoceramide derivative of the present invention is expected to be very useful for treating or preventing skin diseases by activating cannabinoid receptors. In addition, the novel pseudoceramide derivative, the pharmaceutically acceptable salt thereof or the solvate thereof, of the present invention, has a simple synthesis process compared with a known cannabinoid receptor antagonist so as to reduce processing time and curtail material costs, and thus is economical, and has advantages such as easy emulsification during the formulation of cosmetic products or medical supplies.

NEOPHARM CO., LTD.

Ceramide derivatives having agonistic effects on epidermal cannabinoid receptors, and pharmaceutical or cosmetic composition containing same

Provided herein are fixed-dose combination (FDC) compositions comprising therapeutically effective amounts of at least one cannabinoid and spilanthol whether as essentially pure isolates or synthetics or as components of essential oils or plant extracts or combinations thereof. The compositions are formulated as pharmaceutical compositions, nutraceuticals, cosmeceuticals, nutricosmetics, cosmetics, or food products. The pharmaceutical compositions are useful for the treatment of a gastro-enteric disease selected from the group consisting of irritable bowel disease, Crohn's disease, colitis, irritable bowel syndrome, and acute and chronic pancreatitis or of sepsis. Other pharmaceutical uses are as anti-allergic, anti-inflammatory, immunomodulator, antioxidant, anti-microbial, antibacterial, antifungal, antiviral, antinociceptive, analgesic, anesthetic, anti-cancer, apoptosis inducing, antiscorbutic, antipyretic, anti-malarial, addiction mitigatory, anxiolytic, anti-depressant, diuretic, anti-diarrheal, vasodilator or aphrodisiac agents. The pharmaceutical compositions of this invention exhibit a synergistic effect.

SciCann Therapeutics Inc.

SCICANN THERAPEUTICS INC.

Compositions comprising a cannabinoid and spilanthol

The invention relates to the nontherapeutic cosmetic use of at least one cannabinoid compound chosen from the compounds corresponding to general formula (I): ##STR00001## and also the geometric isomers and optical isomers thereof, the cosmetically acceptable acid or base salts thereof, and the hydrates thereof; in which compounds of formula (I): R.sub.1 represents a hydrogen atom or a C.sub.1-C.sub.30 alkyl group; it being possible for said alkyl group to be optionally substituted with a hydroxyl (OH) group; R.sub.2 represents a halogen atom or a group chosen from hydroxyl, thiol (SH), and amino optionally substituted with one or two C.sub.1-C.sub.6 alkyl groups; R.sub.3 and R.sub.4 form, together with the carbon atom which bears them, an oxo group or else R.sub.3 and R.sub.4 represent a hydrogen atom; R.sub.5 represents a hydrogen atom or a C.sub.1-C.sub.6 alkyl group; X represents a heteroatom chosen from oxygen and sulfur atoms and the divalent group --N(R.sub.6)--, with R.sub.6 representing a hydrogen atom or a C.sub.1-C.sub.6 alkyl group; represents a single or double bond; n is 1, 2 or 3, preferentially 1 or 2; it being understood that, when R.sub.3 and R.sub.4 together form an oxo group with the carbon atom which bears them and X represents an oxygen atom, then R.sub.1 cannot represent a hydroxymethyl group, as an agent for coloring keratin materials. It also relates to one of these specific cannabinoid compounds for use thereof in the treatment of vitiligo or pityriasis versicolor, to nontherapeutic cosmetic processes for coloring the skin or for treating canities, comprising the topical application to the skin and/or head hair, or the oral administration, of a composition comprising, in a physiologically acceptable medium, one of these cannabinoid compounds, and to a process for selecting an active agent which promotes the pigmentation of keratin materials.

Zuccolo; Michela

Jourdain; Roland

Breton; Lionel

Maccarrone; Mauro

L'OREAL

Use of cannabinoid compounds for stimulating melanogenesis

Specific compositions comprising one or multiple (cannabinoid) compound(s) of formula (A) and/or one or multiple salt(s) thereof are described as well as methods for their manufacture. ##STR00001## A compound of formula (A), a salt of formula (A) and a respective composition for use as medicine and for use in a method for the therapeutic treatment of the human or animal body, respectively, are also described. Furthermore, corresponding pharmaceutical formulations, cosmetic preparations and foodstuff and/or gourmet or snack preparations fit for consumption as well as a method for the manufacture of delta-9-tetrahydrocannabinol are described.

cosmetic/cannabis

Ceramide derivatives having agonistic effects on epidermal cannabinoid receptors, and pharmaceutical or cosmetic composition containing same

Compositions comprising a cannabinoid and spilanthol

Compositions comprising a cannabinoid and spilanthol

Use of cannabinoid compounds for stimulating melanogenesis

Mixtures of cannabinoid compounds, and production and use thereof

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