cosmos/albumin

OBJECTIVE To survey bone mineral disturbances in the hemodialysis (HD) population in Europe and current clinical practice in Europe for the prevention, diagnosis and treatment of secondary hyperparathyroidism (SHPT) in HD patients. OBJECTIVE First, to estimate the prevalence of Kidney Disease

Models for the prediction of blood-brain partitioning (logBB) and human serum albumin binding (logK(HSA)) of neutral molecules were developed using the set of 5 COSMO-RS sigma-moments as descriptors. These sigma-moments have already been introduced earlier as a general descriptor set for partition

The Cosmos 1887 biosatellite carried 10 male rats and 2 rhesus monkeys on its 12.5-day mission. Upon re-entry the Vostok vehicle overshot the designated landing site, which resulted in fasting of the animals for 42 h, exposure to cage temperatures of 12-15 degrees C, and 2 days delay in death of the

OBJECTIVE The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvir (SIM + SOF). Given the small number of patients treated with the SIM + SOF regimen in

OBJECTIVE This study evaluated the non-inferiority of renoprotection afforded by benidipine versus hydrochlorothiazide in hypertensive patients with chronic kidney disease (CKD). METHODS In this prospective, multicenter, open-labeled, randomized trial, the antialbuminuric effects of benidipine and

Currently the bioaccumulation potential of organic chemicals is assessed in a first tier approach via their octanol-water partition coefficient. This approach has been developed for neutral chemicals and cannot work for ionizable and ionic chemicals because the latter have different

A series of new self-buffering ionic liquids (ILs) based on Good's buffers (GBs) anions and the tetrabutylphosphonium cation ([P4444]+) was here synthesized and characterized. The self-buffering behaviour of the GB-ILs was confirmed by measuring their protonation constants by potentiometry. Further,