ethyl ketone/inflammation

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A case of methyl ethyl ketone peroxide poisoning and a review of complications and their management.

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Methyl Ethyl Ketone Peroxide (MEKP) is a highly toxic clear liquid used as a solvent. It is a strong oxidizing agent and a corrosive. Acute and chronic toxicity can occur as an occupational hazard. Ingestion is associated with corrosive burns leading to stricture formation, inhalational pneumonitis,

Efficacy of active compounds of Chanqin granules on airway neurogenic inflammation induced by PM2.5 in vivo

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Objective: To investigate the efficacy of active compounds of Chanqin (CQ) granules on PM2.5-induced airway neurogenic inflammation in vivo, and to elucidate the underlying mechanisms of action. Methods:

NTP technical report on the toxicity studies of Methyl Ethyl Ketone Peroxide (CAS No. 1338-23-4) in Dimethyl Phthalate (CAS No. 131-11-3) (45:55) Administered Topically in F344/N Rats and B6C3F1 Mice.
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Methyl ethyl ketone peroxide (MEKP) is an unstable organic peroxide used in the manufacture of acrylic resins, as a hardening agent for fiberglass-reinforced plastics, and as a curing agent for unsaturated polyester resins. It is commercially available as a 40% to 60% solution in dimethyl phthalate

Intranasal effects in chemically sensitive volunteers: an experimental exposure study.
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During inhalational exposure to irritants stimulation of the trigeminal nerve endings in the nasal mucosa or other biochemical mechanisms might initiate inflammatory processes. Increased sensitivity of this physiological system in response to chemical stimulation is postulated in subjects reporting

Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential.
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Screening of newly synthesized organic peroxides for tumor initiating/promoting activity would be greatly facilitated if predictive methodologies could be developed using topical exposures shorter than those required for definitive tumor assessment in mouse skin models. Nine organic peroxides

A chronic inhalation toxicity/oncogenicity study of methylethylketoxime in rats and mice.
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To evaluate the oncogenic potential of methylethylketoxime (MEKO), CD-1 mice (50/sex/group) and F-344 rats (50/sex/group) were coexposed 6 h/day, 5 days/wk for 18 mo (mice) or 26 mo (rats) via whole-body inhalation exposures to target vapor concentrations of 0, 15, 75, and 375 ppm (actual

Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture.
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Occupational exposure to volatile organic compounds (VOCs) may cause hematopoietic malignancy, either by single exposure to benzene or possibly due to a concomitant exposure to several VOCs. Since oxidative stress, inflammation and DNA repair pathways are closely involved in cancer development, the

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ethyl ketone/inflammation

A case of methyl ethyl ketone peroxide poisoning and a review of complications and their management.

Efficacy of active compounds of Chanqin granules on airway neurogenic inflammation induced by PM2.5 in vivo

NTP technical report on the toxicity studies of Methyl Ethyl Ketone Peroxide (CAS No. 1338-23-4) in Dimethyl Phthalate (CAS No. 131-11-3) (45:55) Administered Topically in F344/N Rats and B6C3F1 Mice.

Intranasal effects in chemically sensitive volunteers: an experimental exposure study.

Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential.

A chronic inhalation toxicity/oncogenicity study of methylethylketoxime in rats and mice.

Aberrant promoter methylation in genes related to hematopoietic malignancy in workers exposed to a VOC mixture.

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