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Further observations on multinucleated giant cells (MGCs) in 12 giant cell tumors of bone (GCT) were made, by means of tissue culture, electron microscopy and immunohistochemistry. In continuous in vitro culture, two distinct types of MGCs were found and herein termed preliminarily short-lived MGCs
Giant cell tumor (GCT) is one of the most common benign bone tumors, which occurs in young adults 20-40 years old with a high recurrence rate and a potential for aggressive behavior. It is most commonly located at the metaphyseal or epiphyseal portion of the tibia or femur. While overall GCT has a
Tenosynovial giant cell tumors are a group of neoplastic disorders that involve synovium-lined tendon sheaths, synovial joints, and adjacent soft tissue. They are divided into localized and diffuse subtypes. TSGCTs have well-established clinical and histological diagnostic criteria; however, the
Light and electron microscopic investigations and studies of the resorption ability in vitro of giant cells were done in two patients with giant cell osteolytic lesions of metatarsal bone. Giant cells harvested from both patients were similar in morphologic features and ability to resorb dentin.
OBJECTIVE
The aim of the present study was to investigate the relationship of central giant cell granuloma (CGCG) and giant cell tumor of long bones (GCT) with respect to cannibalistic giant cells (GCs).
METHODS
Sixteen cases each of CGCG and GCT were histopathologically analyzed for cannibalistic
Morphological, ultrastructural, and immunohistochemical findings of 12 diffuse type-tenosynovial giant cell tumors/pigmented villonodular synovitis are presented compared to 30 localized tenosynovial giant cell tumors (giant cell tumor of tendon sheath). Diffuse-type-tenosynovial giant cell tumor is
The lengths of desmosomal profiles were measured in sections of tumor tissue from cases of mesothelioma, adenocarcinoma, squamous cell carcinoma, thymoma, and meningioma. Giant desmosomes (length of profile 1 micron or greater than 1 micron) were found in all the above-mentioned tumors except
Thirty-three patients with giant (diameter > or = 4.5 cm) cranial base tumours who underwent surgery at the Hadassah Hospital over the last ten years are described. Twenty-three of the patients had meningiomas, 4 neurinomas, one giant cell tumour, one haemangiopericytoma, and 4 had malignant