Patients with a BMI above 65 kg/m2 that need preoperative conditioning therapy (intervention 1: Liraglutide, intervention 2: aminosteril hepa 8%, intervention 3: Caloric diet with 800 kcal) for weight loss surgery to achieve technical operability.

Morbid Obesity

Bariatric Surgery Candidate

Initially 1.2 mg Liraglutide as subcutaneous daily injection, boosted to 1.8 mg Liraglutide after 3 days subsequently. 1000 ml infusion of aminosteril hepa 8% from day 1 onwards. Caloric diet with 800 kcal from day 1 onwards till technical operability is achieved (about 21 days)

Liraglutide

Aminosteril hepa 8%

Caloric diet with 800 kcal

Sana Klinikum Offenbach

Preoperative Condition in Giant Obese Patients

A Novel Preoperative Conditioning Therapy in Giant Obese Patients With the Combination of Liraglutide and a Leucine-Based Amino-Acid Infusion and Caloric Restriction

Operability means that weight loss surgery could be performed after preoperative condition (due to less visceral fat, less liver volume)

Changing in CRP in g/l during intervention

Changing in white blood cell count /nl during intervention

Changing of liver volume during intervention measured by ultrasound

Changing of GOT in U/l, GPT in U/l, GGT in U/l and AP in U/l

Changing in FEV1 in lung function testing during intervention

Christine Stier

MD, PhD

The subject recruitment was implemented in the obstetrics department of the First People's Hospital of Chongqing Liangjiang New Area, China. 255 pregnant women diagnosed with GDM by IADPSG2010 standard and their children will be enrolled into the GDM group.

In the obstetrics department of Chongqing First People's Hospital of Liangjiang New Area,China,the healthy pregnant women and delivery children in the same period were enrolled into the non-GDM group in a 1:1 ratio.

Gestational Diabetes Mellitus

Children

Growth, Development and Mental health of Children and Adolescence Center

Effects of Gestational Diabetes Mellitus on Children

Effects of Gestational Giabetes Mellitus on Neuropsychological Development and Physique Growth in Children:a Cohort Study

The PDMS-2 test performed at the age of 1 month,3 months,6 months, to compare the differences in test results between the children of the GDM group and the non-GDM group.The PDMS-2 scale included two relatively independent parts, gross motion assessment Scale and fine motion assessment scales. The gross motion assessment scale for infants younger than 1 years of age tests the ability of three areas: reflexes, stationary and locomotion,the fine motion assessment scale tests grasping,visual-motor Integration.The results are expressed in terms of gross motor quotient (GMQ),fine motor quotient (FMQ),and total motor quotient (TMQ).There are seven grades according to quotient(MQ is excellent between 131 and 165, MQ is good between 121 and 130, MQ is medium up between 111 and 120，MQ is medium between 90 and 100，MQ is medium down between 80 and 89, MQ is poor between 70 and 79, MQ is very poor between 35 and 69).

The Gesell developmental scale test was performed at the age of 6 months,12 months,24 months,36 months,48 months,60 months and 72 months,to compare the differences in test results between the children of the GDM group and the non-GDM group.The Gesell developmental scale mainly measures five areas:adaptive behavior, gross motor, fine motor, Language behavior,personal-social behavior, the evaluation finally calculates the developmental quotient (DQ) of each area. Diagnostic criteria: DQ is more than or equal to 86 is normal, DQ is marginal between 76 and 85, DQ is mild mental retardation between 55 and 75, DQ is moderate mental retardation between 40 and 54, DQ is severe mental retardation between 25 and 39, and DQ is less than or equal to 25 is extremely severe mental retardation.

To measure body length/height and weight(mean values were measured three times continuously) at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,and 72 months of age,respectively. And then,WHZ is calculated using WHO2011v3.2.2 software,to compare the differences in WHZ of the children of the GDM group and the non-GDM group.

To measure body length/height(mean values were measured three times continuously) at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,and 72 months of age,respectively. And then,HAZ is calculated using WHO2011v3.2.2 software,to compare the differences in HAZ of the children of the GDM group and the non-GDM group.

To measure body length/height and weight(mean values were measured three times continuously) at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,and 72 months of age,respectively. weight and length/height will be combined to report BMI in kg/m^2.And then,BAZ is calculated using WHO2011v3.2.2 software,to compare the differences in BAZ of the children of the GDM group and the non-GDM group.

To measure body weight(mean values were measured three times continuously) at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,and 72 months of age,respectively. And then,WAZ is calculated using WHO2011v3.2.2 software,to compare the differences in WAZ of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in hemoglobin of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in mean red blood cell volume (MCV) of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in mean red blood cell hemoglobin (MCH) of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in mean red blood cell hemoglobin concentration (MCHC) of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in platelet count (PLT) of the children of the GDM group and the non-GDM group.

Blood routine examinations performed at 1 month,3 months,6 months,12 months,24 months,36 months,48months,60 months,72 months of age,respectively,to compare the differences in percentage of RBC width distribution(RDW%) of the children of the GDM group and the non-GDM group.

giant/obesity

Preoperative Condition in Giant Obese Patients

Effects of Gestational Diabetes Mellitus on Children

Cardiac and Skeletal Muscle Energy Metabolism in Abnormal Growth Hormone States

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