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OBJECTIVE
To establish the identity of a prominent protein, approximately 70 kDa, that is markedly increased in the retina of monkeys with experimental glaucoma compared with the fellow control retina, the relationship to glaucoma severity, and its localization in the retina.
METHODS
Retinal
Numerous studies suggest that reactive oxygen species play a crucial role in the development of glaucoma. Since glaucoma patients exhibit posterior vitreous detachment earlier than controls, it has been suggested that reactive oxygen species-increased in glaucoma-also affect the OBJECTIVE
To compare plasma cortisol binding as well as total plasma cortisol, free cortisol and percent free cortisol in normals, ocular hypertensives and primary high pressure open-angle glaucomas.
METHODS
Blood samples were obtained on outpatient visits of 18 normals, 19 ocular hypertensives and
Determination of tear lysozyme, alfa-1-antitrypsin and serum albumin was performed in the tear fluid of 24 glaucoma patients on maintenance treatment with timolol. In 7 patients with symptoms of dry eye decreased levels of tear lysozyme and increased levels of alfa-1-antitrypsin and serum albumin
Aim: Glaucoma is an optic neuropathy causing progressive impairment of visual functions. We aimed to assess the alterations in thiol-disulfide homeostasis and serum ischemia modified albumin (IMA) levels, which are the determinants of antioxidant status, in patients with primary open-angle
BACKGROUND
This study was carried out in order to improve the understanding of the pathogenesis of uveitic glaucoma.
METHODS
Uveitis was induced in 48 Lewis rats by S-antigen injection. Intraocular pressure (IOP) was measured by Tono-Pen-2 daily for 24 days in 16 animals. Histopathology was
Primary open-angle glaucoma is a disease caused by an increase in intraocular pressure due to a decreased facility of outflow of aqueous humor through the trabecular meshwork. The etiology of primary open-angle glaucoma is currently unknown, but it has been suggested that one possible mechanism may
OBJECTIVE
To clarify the presence of oxidative stress in patients with primary angle-closure glaucoma (PACG) and to investigate the relationship between oxidative stress and PACG.
METHODS
Fifty patients with primary angle-closure glaucoma and fifty healthy controls of matched age and gender were
In 1953, Goldmann observed that outflow resistance increases in an underperfused meshwork and concluded that only continuous perfusion keeps the outflow channels open. In primary open-angle glaucoma densifications occur beneath the inner wall of Schlemm's canal. They consist of fine fibrillary
To introduce a protocol for the characterization of protein patterns in tears of dogs with primary angle closure glaucoma (PACG) and primary open-angle glaucoma (POAG).Nineteen dogs (25 eyes).Tear samples were collected using a IgG and albumin in the aqueous humour and serum were studied using kinetic nephelometry, carried out on 34 eyes with pseudoexfoliation and 31 normal eyes (control group). The results show a rupture in the hemato-aqueous barrier for IgG and albumin in the group of eyes with pseudoexfoliation and
Prostaglandin F(2alpha) analogues have recently been introduced on the market for glaucoma treatment. While these drugs have a well-documented intraocular pressure reducing effect only a limited number of studies have been published regarding their effects on the microvasculature in the eye. Since
Aims: To determine the association between albuminuria and primary open-angle glaucoma (POAG).
Methods: Participants of the Singapore Chinese Eye study were recruited and
Primary open angle glaucoma is a disease which is characterized by a decreased facility of outflow of aqueous humor from the anterior segment of the eye. Analyses by gel exclusion chromatography of the aqueous humor of normal monkeys have shown that the proteins in this fluid range in size from
In a double-blind randomized clinical trial, 79 non-insulin-dependent diabetic subjects with early retinopathy and open-angle glaucoma received orally either three 500-mg capsules of Doxium (calcium dobesilate) daily for 6 months (41 patients) or three placebo capsules daily for the same period (38