A topical skin care lotion includes materials for supplementing the production of collagen I and III includes a base of lipophillic or lipophobic material and at least one amino acid. The amino acids are alanine and glycine. Other components of the lotion include iron, vitamin C, manganese, silica and cherry fruit extract. Together, these components assist the body with the production of collagen and promote healing of damaged skin. Antioxidants are also provided to protect the skin from oxidative stress by ultraviolet sunlight and environmental hazards.

Bennett; Mark K.

Bennett; Mark K

Collagen production compound

The present invention provides novel vitamin E derivatives represented by the following formula (I) wherein: R.sub.1 and R.sub.2 are the same or different and each denotes hydrogen or methyl, R.sub.3 denotes an S-linked SH compound (glutathione, .gamma.-glutamylcysteine, cysteine, penicillamine, an ester thereof or cysteamine), and R.sub.4 denotes hydroxyl, a N-substituted amino acid (glycine, .beta.-alanine, .gamma.-aminobutyric acid, 5-aminovaleric acid, .epsilon.-aminocaproic acid, anthranilic acid, tranexamic acid, proline, an ester thereof, aminoethylsulfonic acid , aminoethylsulfinic acid) or serotonin, or a pharmacologically acceptable salt thereof, which are useful as hepatopathy suppressing agents, anticataract agents, cerebral metabolism improving agents, antioxidants and cosmetic components. ##STR1##

Senju Pharmaceutical Co., Ltd.

Vitamin E derivatives

The invention concerns a functional food preparation based on milk/dairy products added with botanical products containing various active principles. The milk/dairy products, which can be obtained from fresh or pasteurized animal milk, soy milk or rice milk, comprise Saccharum officinarum containing polycosanols, Monascus purpureus containing plant statins, and Glycine max containing isoflavones and coenzymes. Further components can be added to the preparation to improve its organoleptic properties. The invention also refers to the use of the preparation as a food with functional features which are useful to stabilize the cholesterol and triglycerides amount, having an antioxidant action and protective of arteries and the cardiocirculatory system.

Buonamici; Guglielmo

Functional food preparation and use thereof

These and other objects of this invention are achieved by providing a novel method and compositions for the clinical treatment of chronic inflammatory diseases. This invention involves use of systemically administered compositions which include primary amine derivatives of benzoic acid as carbonyl trapping agents. These primary therapeutic agents act by chemically binding to and sequestering the aldehyde and/or ketone products of lipid peroxidation. Increased levels of lipid peroxidation have been repeatedly demonstrated as a part of the non-enzymatic "inflammatory cascade" process which underlies the secondary etiology of chronic inflammatory diseases. p-Aminobenzoic acid (or PABA) is an example of the primary therapeutic agent of the present invention. PABA has a small molecular weight, is water soluble, has a primary amine group that reacts with carbonyl-containing metabolites under physiological conditions and is tolerated by the body in relatively high dosages and for extended periods. The carbonyl sequestering agents are used in combination with at least one co-agent so as to produce an additional beneficial physiological effect of an anti-inflammatory nature. Such compositions are administered systemically entirely via the oral route. Co-agents of the present invention include anti-oxidants and free radical trapping compounds (e.g., .alpha.-tocopherol), compounds having indirect anti-oxidant activity (e.g., selenium), vitamins (e.g., pyridoxine HCl), compounds which facilitate kidney drug elimination (e.g., glycine), metabolites at risk of depletion (e.g., pantothenic acid), sulfhydryl containing chemicals (e.g., methionine), compounds which facilitate glutathione activity (e.g., N-acetylcysteine), and non-absorbable polyamine co-agents (e.g., chitosan).

glycine/抗氧化剂

Collagen production compound

Vitamin E derivatives

Functional food preparation and use thereof

Methods of treating chronic inflammatory diseases using carbonyl trapping agents

科学支持的最完整的草药数据库